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THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.
Blomme A, Peter C, Mui E, Rodriguez Blanco G, An N, Mason LM, Jamieson LE, McGregor GH, Lilla S, Ntala C, Patel R, Thiry M, Kung SHY, Leclercq M, Ford CA, Rushworth LK, McGarry DJ, Mason S, Repiscak P, Nixon C, Salji MJ, Markert E, MacKay GM, Kamphorst JJ, Graham D, Faulds K, Fazli L, Gleave ME, Avezov E, Edwards J, Yin H, Sumpton D, Blyth K, Close P, Murphy DJ, Zanivan S, Leung HY. Blomme A, et al. Among authors: an n. EMBO Mol Med. 2022 Mar 7;14(3):e14764. doi: 10.15252/emmm.202114764. Epub 2022 Jan 11. EMBO Mol Med. 2022. PMID: 35014179 Free PMC article.
The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma.
Shui L, Li X, Peng Y, Tian J, Li S, He D, Li A, Tian B, Li M, Gao H, An N, Yi C, Cao D. Shui L, et al. Among authors: an n. J Transl Med. 2021 Jul 12;19(1):301. doi: 10.1186/s12967-021-02972-6. J Transl Med. 2021. PMID: 34247626 Free PMC article.
DDR pathogenic deficiency was identified in 30 (15.38%) of overall patients, mainly involving BRCA2 (n = 9, 4.62%), ATM (n = 8, 4.10%) and RAD50 genes (n = 3, 1.54%). No significance of OS between patients with or without DDR mutations (p = 0.88). But DDR mut …
DDR pathogenic deficiency was identified in 30 (15.38%) of overall patients, mainly involving BRCA2 (n = 9, 4.62%), ATM (n = 8 …
Cell cycle related genes up-regulated in human colorectal development predict the overall survival of late-stage colorectal cancer patients.
An N, Yang X, Zhang Y, Shi X, Yu X, Cheng S, Zhang K, Wang G. An N, et al. Mol Biosyst. 2016 Feb;12(2):541-52. doi: 10.1039/c5mb00761e. Mol Biosyst. 2016. PMID: 26672738
Notably, 28 cell-cycle related probes within the V probe group were found to be significantly associated with an overall survival of Stage III/IV patients (GSE17536 cross validation, n = 96, p = 5.70 10(-3); GSE29621, n = 36, p = 1.70 10(-3); GSE39084, n …
Notably, 28 cell-cycle related probes within the V probe group were found to be significantly associated with an overall survival of …
1,050 results