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Page 1
Antibody targeting of E3 ubiquitin ligases for receptor degradation.
Marei H, Tsai WK, Kee YS, Ruiz K, He J, Cox C, Sun T, Penikalapati S, Dwivedi P, Choi M, Kan D, Saenz-Lopez P, Dorighi K, Zhang P, Kschonsak YT, Kljavin N, Amin D, Kim I, Mancini AG, Nguyen T, Wang C, Janezic E, Doan A, Mai E, Xi H, Gu C, Heinlein M, Biehs B, Wu J, Lehoux I, Harris S, Comps-Agrar L, Seshasayee D, de Sauvage FJ, Grimmer M, Li J, Agard NJ, de Sousa E Melo F. Marei H, et al. Among authors: mancini ag. Nature. 2022 Oct;610(7930):182-189. doi: 10.1038/s41586-022-05235-6. Epub 2022 Sep 21. Nature. 2022. PMID: 36131013 Free PMC article.
Understanding TERT Promoter Mutations: A Common Path to Immortality.
Bell RJ, Rube HT, Xavier-Magalhães A, Costa BM, Mancini A, Song JS, Costello JF. Bell RJ, et al. Among authors: mancini a. Mol Cancer Res. 2016 Apr;14(4):315-23. doi: 10.1158/1541-7786.MCR-16-0003. Epub 2016 Mar 3. Mol Cancer Res. 2016. PMID: 26941407 Free PMC article. Review.
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing.
Balke-Want H, Keerthi V, Gkitsas N, Mancini AG, Kurgan GL, Fowler C, Xu P, Liu X, Asano K, Patel S, Fisher CJ, Brown AK, Tunuguntla RH, Patel S, Sotillo E, Mackall CL, Feldman SA. Balke-Want H, et al. Among authors: mancini ag. Mol Cancer. 2023 Jun 26;22(1):100. doi: 10.1186/s12943-023-01799-7. Mol Cancer. 2023. PMID: 37365642 Free PMC article.
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF. Amen AM, et al. Among authors: mancini a. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2008772118. doi: 10.1073/pnas.2008772118. Proc Natl Acad Sci U S A. 2021. PMID: 33758097 Free PMC article.
Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis.
Kurtova AV, Heinlein M, Haas S, Velten L, Dijkgraaf GJP, Storm EE, Kljavin NM, Boumahdi S, Himmels P, Herault A, Mancini A, Koeppen H, Dail M, Yan Q, Zhang J, Koch U, Radtke F, Modrusan Z, Metcalfe C, Piskol R, de Sauvage FJ. Kurtova AV, et al. Among authors: mancini a. Blood Adv. 2023 Feb 28;7(4):491-507. doi: 10.1182/bloodadvances.2022007714. Blood Adv. 2023. PMID: 35914228 Free PMC article.
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF. Mancini A, et al. Cancer Cell. 2018 Sep 10;34(3):513-528.e8. doi: 10.1016/j.ccell.2018.08.003. Cancer Cell. 2018. PMID: 30205050 Free PMC article.
Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process.
Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO. Ohba S, et al. Among authors: mancini a. Cancer Res. 2016 Nov 15;76(22):6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6. Cancer Res. 2016. PMID: 27758882 Free PMC article.