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Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah-/-mdx Mice.
Martin PT, Kawanishi K, Ashbrook A, Golden B, Samraj A, Crowe KE, Zygmunt DA, Okerblom J, Yu H, Maki A, Diaz S, Chen X, Janssen PML, Varki A. Martin PT, et al. Among authors: ashbrook a. Am J Pathol. 2021 Aug;191(8):1474-1486. doi: 10.1016/j.ajpath.2021.04.015. Am J Pathol. 2021. PMID: 34294193 Free PMC article.
Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength.
Martin PT, Zygmunt DA, Ashbrook A, Hamilton S, Packer D, Birch SM, Bettis AK, Balog-Alvarez CJ, Guo LJ, Nghiem PP, Kornegay JN. Martin PT, et al. Among authors: ashbrook a. PLoS One. 2021 Mar 26;16(3):e0248721. doi: 10.1371/journal.pone.0248721. eCollection 2021. PLoS One. 2021. PMID: 33770101 Free PMC article.