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Page 1
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.
Bioorg Med Chem Lett. 2021 Jun 1;41:127973. doi: 10.1016/j.bmcl.2021.127973. Epub 2021 Mar 19.
Bioorg Med Chem Lett. 2021.
PMID: 33753261
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
Lomas DA, Irving JA, Arico-Muendel C, Belyanskaya S, Brewster A, Brown M, Chung CW, Dave H, Denis A, Dodic N, Dossang A, Eddershaw P, Klimaszewska D, Haq I, Holmes DS, Hutchinson JP, Jagger AM, Jakhria T, Jigorel E, Liddle J, Lind K, Marciniak SJ, Messer J, Neu M, Olszewski A, Ordonez A, Ronzoni R, Rowedder J, Rüdiger M, Skinner S, Smith KJ, Terry R, Trottet L, Uings I, Wilson S, Zhu Z, Pearce AC.
Lomas DA, et al. Among authors: dossang a.
EMBO Mol Med. 2021 Mar 5;13(3):e13167. doi: 10.15252/emmm.202013167. Epub 2021 Jan 29.
EMBO Mol Med. 2021.
PMID: 33512066
Free PMC article.
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Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
Gavory G, O'Dowd CR, Helm MD, Flasz J, Arkoudis E, Dossang A, Hughes C, Cassidy E, McClelland K, Odrzywol E, Page N, Barker O, Miel H, Harrison T.
Gavory G, et al. Among authors: dossang a.
Nat Chem Biol. 2018 Feb;14(2):118-125. doi: 10.1038/nchembio.2528. Epub 2017 Dec 4.
Nat Chem Biol. 2018.
PMID: 29200206
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The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.
Dossang AC, Motshwene PG, Yang Y, Symmons MF, Bryant CE, Borman S, George J, Weber AN, Gay NJ.
Dossang AC, et al.
Sci Rep. 2016 Nov 23;6:37267. doi: 10.1038/srep37267.
Sci Rep. 2016.
PMID: 27876844
Free PMC article.
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