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A carboxy-terminal truncation of human alpha-galactosidase A in a heterozygous female with Fabry disease and modification of the enzymatic activity by the carboxy-terminal domain. Increased, reduced, or absent enzyme activity depending on number of amino acid residues deleted.
Miyamura N, Araki E, Matsuda K, Yoshimura R, Furukawa N, Tsuruzoe K, Shirotani T, Kishikawa H, Yamaguchi K, Shichiri M. Miyamura N, et al. Among authors: araki e. J Clin Invest. 1996 Oct 15;98(8):1809-17. doi: 10.1172/JCI118981. J Clin Invest. 1996. PMID: 8878432 Free PMC article.
Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling.
Yoshimura R, Araki E, Ura S, Todaka M, Tsuruzoe K, Furukawa N, Motoshima H, Yoshizato K, Kaneko K, Matsuda K, Kishikawa H, Shichiri M. Yoshimura R, et al. Among authors: araki e. Diabetes. 1997 Jun;46(6):929-36. doi: 10.2337/diab.46.6.929. Diabetes. 1997. PMID: 9166661
Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Gö 6976-insensitive pathway.
Furukawa N, Shirotani T, Araki E, Kaneko K, Todaka M, Matsumoto K, Tsuruzoe K, Motoshima H, Yoshizato K, Kishikawa H, Shichiri M. Furukawa N, et al. Among authors: araki e. Endocr J. 1999 Feb;46(1):43-58. doi: 10.1507/endocrj.46.43. Endocr J. 1999. PMID: 10426567 Free article.
Regulation of the insulin gene transcription by glucose.
Furukawa N, Shirotani T, Nakamaru K, Matsumoto K, Shichiri M, Araki E. Furukawa N, et al. Among authors: araki e. Endocr J. 2002 Apr;49(2):121-30. doi: 10.1507/endocrj.49.121. Endocr J. 2002. PMID: 12081229 Free article. Review. No abstract available.
435 results