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2020 1
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2023 1
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Page 1
Dipping a toe in the fountain of youth.
Markel A, Daley GQ. Markel A, et al. Nat Aging. 2022 Mar;2(3):192-194. doi: 10.1038/s43587-022-00188-x. Nat Aging. 2022. PMID: 37118376 No abstract available.
Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4-/- mouse model of PFIC3.
Wei G, Cao J, Huang P, An P, Badlani D, Vaid KA, Zhao S, Wang DQ, Zhuo J, Yin L, Frassetto A, Markel A, Presnyak V, Gandham S, Hua S, Lukacs C, Finn PF, Giangrande PH, Martini PGV, Popov YV. Wei G, et al. Among authors: markel a. J Hepatol. 2021 Jun;74(6):1416-1428. doi: 10.1016/j.jhep.2020.12.010. Epub 2020 Dec 17. J Hepatol. 2021. PMID: 33340584 Free PMC article.
Biocoating-A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles.
Azagury A, Baptista C, Milovanovic K, Shin H, Morello P 3rd, Perez-Rogers J, Goldenshtein V, Nguyen T, Markel A, Rege S, Hojsak S, Perl A, Jones C, Fife M, Furtado S, Mathiowitz E. Azagury A, et al. Among authors: markel a. Small. 2022 Jul;18(26):e2107559. doi: 10.1002/smll.202107559. Epub 2022 May 23. Small. 2022. PMID: 35606684 Free PMC article.
mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease.
Cao J, Choi M, Guadagnin E, Soty M, Silva M, Verzieux V, Weisser E, Markel A, Zhuo J, Liang S, Yin L, Frassetto A, Graham AR, Burke K, Ketova T, Mihai C, Zalinger Z, Levy B, Besin G, Wolfrom M, Tran B, Tunkey C, Owen E, Sarkis J, Dousis A, Presnyak V, Pepin C, Zheng W, Ci L, Hard M, Miracco E, Rice L, Nguyen V, Zimmer M, Rajarajacholan U, Finn PF, Mithieux G, Rajas F, Martini PGV, Giangrande PH. Cao J, et al. Among authors: markel a. Nat Commun. 2021 May 25;12(1):3090. doi: 10.1038/s41467-021-23318-2. Nat Commun. 2021. PMID: 34035281 Free PMC article.
Amnio acid substitution at position 298 of human glucose-6 phosphatase-α significantly impacts its stability in mammalian cells.
Cao J, Markel A, Hanahoe E, Ketova T, Mihai C, Zalinger Z, Marquardt D, Amato NJ, Cheng YM, Reid DW, Dousis A, Giangrande PH, Schultz JR, Martini PGV, Finn PF. Cao J, et al. Among authors: markel a. Amino Acids. 2023 May;55(5):695-708. doi: 10.1007/s00726-023-03263-8. Epub 2023 Mar 21. Amino Acids. 2023. PMID: 36944899 Free PMC article.