Haematological characteristics and spontaneous haematological recovery in Pearson syndrome

Ayami Yoshimi; Sarah C Grünert; Holger Cario; Aron Fisch; Ute Gross-Wieltsch; Kirsten Timmermann; Udo Kontny; Stephan Lobitz; Helen S Odenthal; Irene Schmid; Barbara Uetz; Tanja Höll; Agnès Rötig; Thomas Lücke; Arndt Borkhardt; Gabriele Strauß; Alexander Hohnecker; Markus Metzler; Daniela Karall; Charlotte M Niemeyer

doi:10.1111/bjh.17434

Haematological characteristics and spontaneous haematological recovery in Pearson syndrome

Br J Haematol. 2021 Jun;193(6):1283-1287. doi: 10.1111/bjh.17434. Epub 2021 Apr 10.

Authors

Ayami Yoshimi¹, Sarah C Grünert², Holger Cario³, Aron Fisch¹, Ute Gross-Wieltsch⁴, Kirsten Timmermann⁵, Udo Kontny⁶, Stephan Lobitz⁷, Helen S Odenthal⁸, Irene Schmid⁹, Barbara Uetz¹⁰, Tanja Höll¹¹, Agnès Rötig¹², Thomas Lücke¹³, Arndt Borkhardt¹⁴, Gabriele Strauß^{15

16}, Alexander Hohnecker¹⁷, Markus Metzler¹⁸, Daniela Karall¹⁹, Charlotte M Niemeyer¹

Affiliations

¹ Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
² Department of General Paediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, University Medical Center, University of Freiburg, Freiburg, Germany.
³ Department of Paediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
⁴ Paediatric Oncology, Haematology, Immunology, Klinikum Stuttgart - Olgahospital, Stuttgart, Germany.
⁵ Paediatric Nephrology, Klinikum Stuttgart - Olgahospital, Stuttgart, Germany.
⁶ Department of Haematology, Oncology and Stem Cell Transplantation, RWTH Aachen University Medical School, Aachen, Germany.
⁷ Department of Paediatric Haematology/Oncology, Gemeinschaftsklinikum Mittelrhein, Koblenz, Germany.
⁸ Department of Paediatric Oncology/Haematology, Kinderkrankenhaus Amsterdamer Straße, Cologne, Germany.
⁹ Division of Paediatric Haematology and Oncology, Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany.
¹⁰ KfH Center of Paediatric Nephrology, Children's Hospital Munich Schwabing, Munich, Germany.
¹¹ Department of Paediatric Haematology and Oncology, Sana Kliniken, Duisburg, Germany.
¹² Université de Paris, Imagine Institute, Laboratory of Genetics of Mitochondrial diseases, INSERM UMR 1163, Paris, France.
¹³ University Children's Hospital, Ruhr University, Bochum, Germany.
¹⁴ Department of Paediatric Oncology, Haematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
¹⁵ Department of Paediatrics and Adolescent Medicine, Helios Hospital Berlin-Buch, Berlin, Germany.
¹⁶ Department of Paediatric Oncology/Haematology/Stem Cell Transplantation, Charité Campus Virchow-Klinikum, Berlin, Germany.
¹⁷ Department of Paediatric, Dritter Orden Clinic, Munich, Germany.
¹⁸ Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.
¹⁹ Medical University of Innsbruck, Clinic for Paediatrics, Inherited Metabolic Disorders, Innsbruck, Austria.

PMID: 33837965
DOI: 10.1111/bjh.17434

No abstract available

Keywords: Pearson syndrome; hematological recovery; mitochondrial disease; single large-scale mitochondrial DNA deletion.

Publication types

Letter

MeSH terms

Child, Preschool
Congenital Bone Marrow Failure Syndromes / blood*
Female
Humans
Infant
Lipid Metabolism, Inborn Errors / blood*
Male
Mitochondrial Diseases / blood*
Muscular Diseases / blood*
Recovery of Function
Remission, Spontaneous*

Supplementary concepts

VLCAD deficiency