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Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation.
Mishra S, Welch N, Karthikeyan M, Bellar A, Musich R, Singh SS, Zhang D, Sekar J, Attaway AH, Chelluboyina AK, Lorkowski SW, Roychowdhury S, Li L, Willard B, Smith JD, Hoppel CL, Vachharajani V, Kumar A, Dasarathy S. Mishra S, et al. Among authors: chelluboyina ak. Aging Cell. 2023 Jul;22(7):e13852. doi: 10.1111/acel.13852. Epub 2023 Apr 26. Aging Cell. 2023. PMID: 37101412 Free PMC article.
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
Welch N, Singh SS, Kumar A, Dhruba SR, Mishra S, Sekar J, Bellar A, Attaway AH, Chelluboyina A, Willard BB, Li L, Huo Z, Karnik SS, Esser K, Longworth MS, Shah YM, Davuluri G, Pal R, Dasarathy S. Welch N, et al. Among authors: chelluboyina a. J Biol Chem. 2021 Sep;297(3):101023. doi: 10.1016/j.jbc.2021.101023. Epub 2021 Jul 31. J Biol Chem. 2021. PMID: 34343564 Free PMC article.
Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function.
Kanumuri R, Chelluboyina AK, Biswal J, Vignesh R, Pandian J, Venu A, Vaishnavi B, Leena DJ, Jeyaraman J, Ganesan K, Aradhyam GK, Venkatraman G, Rayala SK. Kanumuri R, et al. Among authors: chelluboyina ak. Oncogene. 2021 Aug;40(34):5327-5341. doi: 10.1038/s41388-021-01927-x. Epub 2021 Jul 12. Oncogene. 2021. PMID: 34253860
Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer.
Blum AE, Venkitachalam S, Ravillah D, Chelluboyina AK, Kieber-Emmons AM, Ravi L, Kresak A, Chandar AK, Markowitz SD, Canto MI, Wang JS, Shaheen NJ, Guo Y, Shyr Y, Willis JE, Chak A, Varadan V, Guda K. Blum AE, et al. Among authors: chelluboyina ak. Gastroenterology. 2019 May;156(6):1761-1774. doi: 10.1053/j.gastro.2019.01.263. Epub 2019 Feb 12. Gastroenterology. 2019. PMID: 30768984 Free PMC article.