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Page 1
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
Liu Y, Bunney TD, Khosa S, Macé K, Beckenbauer K, Askwith T, Maslen S, Stubbs C, de Oliveira TM, Sader K, Skehel M, Gavin AC, Phillips C, Katan M. Liu Y, et al. Among authors: askwith t. EBioMedicine. 2020 Jan;51:102607. doi: 10.1016/j.ebiom.2019.102607. Epub 2020 Jan 6. EBioMedicine. 2020. PMID: 31918402 Free PMC article.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: askwith t. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Among authors: askwith t. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.
Emerging drugs for diabetic neuropathy.
Tahrani AA, Askwith T, Stevens MJ. Tahrani AA, et al. Among authors: askwith t. Expert Opin Emerg Drugs. 2010 Dec;15(4):661-83. doi: 10.1517/14728214.2010.512610. Epub 2010 Aug 27. Expert Opin Emerg Drugs. 2010. PMID: 20795891 Review.
Mast cells: a unique source of renin.
Silver RB, Reid AC, Mackins CJ, Askwith T, Schaefer U, Herzlinger D, Levi R. Silver RB, et al. Among authors: askwith t. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13607-12. doi: 10.1073/pnas.0403208101. Epub 2004 Sep 1. Proc Natl Acad Sci U S A. 2004. PMID: 15342908 Free PMC article.