Aubrey BJ - Search Results

1

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.

Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. Kotschy A, et al. Among authors: aubrey bj. Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19. Nature. 2016. PMID: 27760111

2

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Kelly GL, et al. Among authors: aubrey bj. Genes Dev. 2014 Jan 1;28(1):58-70. doi: 10.1101/gad.232009.113. Genes Dev. 2014. PMID: 24395247 Free PMC article.

3

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.

Aubrey BJ, Kelly GL, Kueh AJ, Brennan MS, O'Connor L, Milla L, Wilcox S, Tai L, Strasser A, Herold MJ. Aubrey BJ, et al. Cell Rep. 2015 Mar 3;10(8):1422-32. doi: 10.1016/j.celrep.2015.02.002. Epub 2015 Feb 26. Cell Rep. 2015. PMID: 25732831 Free article.

4

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

Valente LJ, Aubrey BJ, Herold MJ, Kelly GL, Happo L, Scott CL, Newbold A, Johnstone RW, Huang DC, Vassilev LT, Strasser A. Valente LJ, et al. Among authors: aubrey bj. Cell Rep. 2016 Mar 1;14(8):1858-66. doi: 10.1016/j.celrep.2016.01.059. Epub 2016 Feb 18. Cell Rep. 2016. PMID: 26904937 Free article.

5

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.

Grabow S, Delbridge AR, Aubrey BJ, Vandenberg CJ, Strasser A. Grabow S, et al. Among authors: aubrey bj. Cell Rep. 2016 Mar 15;14(10):2337-47. doi: 10.1016/j.celrep.2016.02.039. Epub 2016 Mar 3. Cell Rep. 2016. PMID: 26947081 Free article.

6

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

Xu Z, Sharp PP, Yao Y, Segal D, Ang CH, Khaw SL, Aubrey BJ, Gong J, Kelly GL, Herold MJ, Strasser A, Roberts AW, Alexander WS, Burns CJ, Huang DC, Glaser SP. Xu Z, et al. Among authors: aubrey bj. Leukemia. 2016 Jul;30(7):1531-41. doi: 10.1038/leu.2016.52. Epub 2016 Mar 8. Leukemia. 2016. PMID: 27055867

7

Tumor-Suppressor Functions of the TP53 Pathway.

Aubrey BJ, Strasser A, Kelly GL. Aubrey BJ, et al. Cold Spring Harb Perspect Med. 2016 May 2;6(5):a026062. doi: 10.1101/cshperspect.a026062. Cold Spring Harb Perspect Med. 2016. PMID: 27141080 Free PMC article. Review.

8

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

Delbridge AR, Pang SH, Vandenberg CJ, Grabow S, Aubrey BJ, Tai L, Herold MJ, Strasser A. Delbridge AR, et al. Among authors: aubrey bj. J Exp Med. 2016 Sep 19;213(10):2039-48. doi: 10.1084/jem.20150477. Epub 2016 Sep 12. J Exp Med. 2016. PMID: 27621418 Free PMC article.

9

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.

Delbridge AR, Aubrey BJ, Hyland C, Bernardini JP, Di Rago L, Garnier JM, Lessene G, Strasser A, Alexander WS, Grabow S. Delbridge AR, et al. Among authors: aubrey bj. Cell Death Dis. 2017 Jul 6;8(7):e2914. doi: 10.1038/cddis.2017.304. Cell Death Dis. 2017. PMID: 28682312 Free PMC article.

10

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. Aubrey BJ, et al. Cell Death Differ. 2018 Jan;25(1):104-113. doi: 10.1038/cdd.2017.169. Epub 2017 Nov 17. Cell Death Differ. 2018. PMID: 29149101 Free PMC article. Review.

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