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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. O'Brien C, et al. Among authors: astori a. Haematologica. 2023 Sep 1;108(9):2343-2357. doi: 10.3324/haematol.2022.281894. Haematologica. 2023. PMID: 37021547 Free PMC article.
SARS-CoV-2 targets ribosomal RNA biogenesis.
Yerlici VT, Astori A, Kejiou NS, Jordan CA, Khosraviani N, Chan JNY, Hakem R, Raught B, Palazzo AF, Mekhail K. Yerlici VT, et al. Among authors: astori a. Cell Rep. 2024 Mar 26;43(3):113891. doi: 10.1016/j.celrep.2024.113891. Epub 2024 Feb 29. Cell Rep. 2024. PMID: 38427561 Free article.
Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors.
Chan K, Farias AG, Lee H, Guvenc F, Mero P, Brown KR, Ward H, Billmann M, Aulakh K, Astori A, Haider S, Marcon E, Braunschweig U, Pu S, Habsid A, Yan Tong AH, Christie-Holmes N, Budylowski P, Ghalami A, Mubareka S, Maguire F, Banerjee A, Mossman KL, Greenblatt J, Gray-Owen SD, Raught B, Blencowe BJ, Taipale M, Myers C, Moffat J. Chan K, et al. Among authors: astori a. Heliyon. 2023 Jan;9(1):e12744. doi: 10.1016/j.heliyon.2022.e12744. Epub 2022 Dec 30. Heliyon. 2023. PMID: 36597481 Free PMC article.
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses.
Mekhail K, Lee M, Sugiyama M, Astori A, St-Germain J, Latreille E, Khosraviani N, Wei K, Li Z, Rini J, Lee WL, Antonescu C, Raught B, Fairn GD. Mekhail K, et al. Among authors: astori a. J Lipid Res. 2022 Sep;63(9):100256. doi: 10.1016/j.jlr.2022.100256. Epub 2022 Jul 31. J Lipid Res. 2022. PMID: 35921881 Free PMC article.
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
Astori A, Matherat G, Munoz I, Gautier EF, Surdez D, Zermati Y, Verdier F, Zaidi S, Feuillet V, Kadi A, Lauret E, Delattre O, Lefèvre C, Fontenay M, Ségal-Bendirdjian E, Dusanter-Fourt I, Bouscary D, Hermine O, Mayeux P, Pendino F. Astori A, et al. Haematologica. 2022 Jan 1;107(1):268-283. doi: 10.3324/haematol.2020.263558. Haematologica. 2022. PMID: 33241676 Free PMC article.
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation.
Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F. Bruserud Ø, et al. Among authors: astori a. Oncotarget. 2015 Feb 20;6(5):2794-811. doi: 10.18632/oncotarget.3056. Oncotarget. 2015. PMID: 25605239 Free PMC article.