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Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.
Griffith BP, Goerlich CE, Singh AK, Rothblatt M, Lau CL, Shah A, Lorber M, Grazioli A, Saharia KK, Hong SN, Joseph SM, Ayares D, Mohiuddin MM. Griffith BP, et al. Among authors: ayares d. N Engl J Med. 2022 Jul 7;387(1):35-44. doi: 10.1056/NEJMoa2201422. Epub 2022 Jun 22. N Engl J Med. 2022. PMID: 35731912 Free PMC article.
Life-supporting function of genetically modified swine lungs in baboons.
Nguyen BN, Azimzadeh AM, Zhang T, Wu G, Schuurman HJ, Sachs DH, Ayares D, Allan JS, Pierson RN 3rd. Nguyen BN, et al. Among authors: ayares d. J Thorac Cardiovasc Surg. 2007 May;133(5):1354-63. doi: 10.1016/j.jtcvs.2006.11.043. Epub 2007 Apr 2. J Thorac Cardiovasc Surg. 2007. PMID: 17467457 Free article.
Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.
Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Dabkowski NL, Belli AJ, Reimann KA, Ayares D, Horvath KA. Mohiuddin MM, et al. Among authors: ayares d. Xenotransplantation. 2014 Jan-Feb;21(1):35-45. doi: 10.1111/xen.12066. Epub 2013 Oct 29. Xenotransplantation. 2014. PMID: 24164510 Free PMC article.
One-year heterotopic cardiac xenograft survival in a pig to baboon model.
Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Reimann KA, Klymiuk N, Wolf E, Ayares D, Horvath KA. Mohiuddin MM, et al. Among authors: ayares d. Am J Transplant. 2014 Feb;14(2):488-9. doi: 10.1111/ajt.12562. Epub 2013 Dec 11. Am J Transplant. 2014. PMID: 24330419 Free PMC article. No abstract available.
Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation.
Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Ayares D, Horvath KA. Mohiuddin MM, et al. Among authors: ayares d. J Thorac Cardiovasc Surg. 2014 Sep;148(3):1106-13; discussion 1113-4. doi: 10.1016/j.jtcvs.2014.06.002. Epub 2014 Jun 6. J Thorac Cardiovasc Surg. 2014. PMID: 24998698 Free PMC article.
Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.
Azimzadeh AM, Kelishadi SS, Ezzelarab MB, Singh AK, Stoddard T, Iwase H, Zhang T, Burdorf L, Sievert E, Avon C, Cheng X, Ayares D, Horvath KA, Corcoran PC, Mohiuddin MM, Barth RN, Cooper DK, Pierson RN 3rd. Azimzadeh AM, et al. Among authors: ayares d. Xenotransplantation. 2015 Jul-Aug;22(4):310-6. doi: 10.1111/xen.12176. Epub 2015 Jul 14. Xenotransplantation. 2015. PMID: 26174749 Free PMC article.
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft.
Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson Iii RN, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, Horvath KA. Mohiuddin MM, et al. Among authors: ayares d. Nat Commun. 2016 Apr 5;7:11138. doi: 10.1038/ncomms11138. Nat Commun. 2016. PMID: 27045379 Free PMC article.
219 results