Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy.
Hensel N, Cieri F, Santonicola P, Tapken I, Schüning T, Taiana M, Pagliari E, Joseph A, Fischer S, Heidrich N, Brinkmann H, Kubinski S, Bergmann AK, Richter MF, Jung K, Corti S, Di Schiavi E, Claus P.
Hensel N, et al. Among authors: heidrich n.
Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2007785118. doi: 10.1073/pnas.2007785118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33931501
Free PMC article.
The SMA network is structured in two clusters with AKT and 14-3-3 zeta/delta in their centers. Both clusters are connected by B-Raf as a major signaling hub. The direct interaction of B-Raf with 14-3-3 zeta/delta is important for an efficient neurotrophic activation …
The SMA network is structured in two clusters with AKT and 14-3-3 zeta/delta in their centers. Both clusters are connected by B-Raf a …