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A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.
Montagnese S, Lauridsen M, Vilstrup H, Zarantonello L, Lakner G, Fitilev S, Zupanets I, Kozlova I, Bunkova E, Tomasiewicz K, Berglund JE, Rorsman F, Hagström H, Kechagias S, Ocklind CE, Mauney J, Thunarf F, Mokhatarani M, Bäckström T, Doverskog M, Lins LE, Månsson M, Samuelson P, Nilsson D, Schalling M, Johansson M, Arlander E, Scharschmidt BF. Montagnese S, et al. Among authors: backstrom t. J Hepatol. 2021 Jul;75(1):98-107. doi: 10.1016/j.jhep.2021.03.012. Epub 2021 Apr 21. J Hepatol. 2021. PMID: 33894327 Free article. Clinical Trial.
GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.
Johansson M, Agusti A, Llansola M, Montoliu C, Strömberg J, Malinina E, Ragagnin G, Doverskog M, Bäckström T, Felipo V. Johansson M, et al. Among authors: backstrom t. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G400-9. doi: 10.1152/ajpgi.00073.2015. Epub 2015 Jul 2. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26138462 Free PMC article.
361 results