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Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas.
Ijare OB, Hambarde S, Brasil da Costa FH, Lopez S, Sharpe MA, Helekar SA, Hangel G, Bogner W, Widhalm G, Bachoo RM, Baskin DS, Pichumani K. Ijare OB, et al. Among authors: bachoo rm. Neuro Oncol. 2022 Apr 1;24(4):556-568. doi: 10.1093/neuonc/noab219. Neuro Oncol. 2022. PMID: 34515312 Free PMC article.
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.
Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM. Mashimo T, et al. Among authors: bachoo rm. Cell. 2014 Dec 18;159(7):1603-14. doi: 10.1016/j.cell.2014.11.025. Cell. 2014. PMID: 25525878 Free PMC article.
Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.
Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA. Courtney KD, et al. Among authors: bachoo rm. Cell Metab. 2018 Nov 6;28(5):793-800.e2. doi: 10.1016/j.cmet.2018.07.020. Epub 2018 Aug 23. Cell Metab. 2018. PMID: 30146487 Free PMC article.
Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.
Jakkamsetti V, Marin-Valencia I, Ma Q, Good LB, Terrill T, Rajasekaran K, Pichumani K, Khemtong C, Hooshyar MA, Sundarrajan C, Patel MS, Bachoo RM, Malloy CR, Pascual JM. Jakkamsetti V, et al. Among authors: bachoo rm. Sci Transl Med. 2019 Feb 20;11(480):eaan0457. doi: 10.1126/scitranslmed.aan0457. Sci Transl Med. 2019. PMID: 30787166 Free PMC article.
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen J, Sun X, Mickey B, Choi C, Takahashi M, Togao O, Pascual JM, Deberardinis RJ, Maher EA, Malloy CR, Bachoo RM. Marin-Valencia I, et al. Among authors: bachoo rm. NMR Biomed. 2012 Oct;25(10):1177-86. doi: 10.1002/nbm.2787. Epub 2012 Mar 1. NMR Biomed. 2012. PMID: 22383401 Free PMC article.
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM. Marin-Valencia I, et al. Among authors: bachoo rm. Cell Metab. 2012 Jun 6;15(6):827-37. doi: 10.1016/j.cmet.2012.05.001. Cell Metab. 2012. PMID: 22682223 Free PMC article.
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