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Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
Chandran SS, Ma J, Klatt MG, Dündar F, Bandlamudi C, Razavi P, Wen HY, Weigelt B, Zumbo P, Fu SN, Banks LB, Yi F, Vercher E, Etxeberria I, Bestman WD, Da Cruz Paula A, Aricescu IS, Drilon A, Betel D, Scheinberg DA, Baker BM, Klebanoff CA. Chandran SS, et al. Among authors: baker bm. Nat Med. 2022 May;28(5):946-957. doi: 10.1038/s41591-022-01786-3. Epub 2022 Apr 28. Nat Med. 2022. PMID: 35484264 Free PMC article.
Structure Based Prediction of Neoantigen Immunogenicity.
Riley TP, Keller GLJ, Smith AR, Davancaze LM, Arbuiso AG, Devlin JR, Baker BM. Riley TP, et al. Among authors: baker bm. Front Immunol. 2019 Aug 28;10:2047. doi: 10.3389/fimmu.2019.02047. eCollection 2019. Front Immunol. 2019. PMID: 31555277 Free PMC article.
Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Devlin JR, Alonso JA, Ayres CM, Keller GLJ, Bobisse S, Vander Kooi CW, Coukos G, Gfeller D, Harari A, Baker BM. Devlin JR, et al. Among authors: baker bm. Nat Chem Biol. 2020 Nov;16(11):1269-1276. doi: 10.1038/s41589-020-0610-1. Epub 2020 Aug 17. Nat Chem Biol. 2020. PMID: 32807968 Free PMC article.
An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.
Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM. Singh NK, et al. Among authors: baker bm. Biochemistry. 2020 Nov 3;59(43):4163-4175. doi: 10.1021/acs.biochem.0c00689. Epub 2020 Oct 19. Biochemistry. 2020. PMID: 33074657 Free PMC article.
Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting.
Schmidt J, Smith AR, Magnin M, Racle J, Devlin JR, Bobisse S, Cesbron J, Bonnet V, Carmona SJ, Huber F, Ciriello G, Speiser DE, Bassani-Sternberg M, Coukos G, Baker BM, Harari A, Gfeller D. Schmidt J, et al. Among authors: baker bm. Cell Rep Med. 2021 Feb 6;2(2):100194. doi: 10.1016/j.xcrm.2021.100194. eCollection 2021 Feb 16. Cell Rep Med. 2021. PMID: 33665637 Free PMC article.
278 results