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N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA. Chui AJ, et al. Among authors: ball dp. Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14. Science. 2019. PMID: 30872531 Free PMC article.
Caspase-1 interdomain linker cleavage is required for pyroptosis.
Ball DP, Taabazuing CY, Griswold AR, Orth EL, Rao SD, Kotliar IB, Vostal LE, Johnson DC, Bachovchin DA. Ball DP, et al. Life Sci Alliance. 2020 Feb 12;3(3):e202000664. doi: 10.26508/lsa.202000664. Print 2020 Mar. Life Sci Alliance. 2020. PMID: 32051255 Free PMC article.
Activation of the CARD8 Inflammasome Requires a Disordered Region.
Chui AJ, Griswold AR, Taabazuing CY, Orth EL, Gai K, Rao SD, Ball DP, Hsiao JC, Bachovchin DA. Chui AJ, et al. Among authors: ball dp. Cell Rep. 2020 Oct 13;33(2):108264. doi: 10.1016/j.celrep.2020.108264. Cell Rep. 2020. PMID: 33053349 Free PMC article.
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
Rao SD, Chen Q, Wang Q, Orth-He EL, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Huang HC, Chui AJ, Covelli DJ, You S, Cross JR, Bachovchin DA. Rao SD, et al. Among authors: ball dp. Nat Chem Biol. 2022 May;18(5):565-574. doi: 10.1038/s41589-021-00964-7. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165443 Free PMC article.
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.
Ball DP, Tsamouri LP, Wang AE, Huang HC, Warren CD, Wang Q, Edmondson IH, Griswold AR, Rao SD, Johnson DC, Bachovchin DA. Ball DP, et al. Sci Immunol. 2022 Nov 11;7(77):eabm7200. doi: 10.1126/sciimmunol.abm7200. Epub 2022 Nov 4. Sci Immunol. 2022. PMID: 36332009 Free PMC article.
The NLRP1 and CARD8 inflammasomes detect reductive stress.
Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA. Wang Q, et al. Among authors: ball dp. Cell Rep. 2023 Jan 31;42(1):111966. doi: 10.1016/j.celrep.2022.111966. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649710 Free PMC article.
22 results