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Page 1
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Liddle J, Bamborough P, Barker MD, Campos S, Cousins RP, Cutler GJ, Hobbs H, Holmes DS, Ioannou C, Mellor GW, Morse MA, Payne JJ, Pritchard JM, Smith KJ, Tape DT, Whitworth C, Williamson RA. Liddle J, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2009 May 1;19(9):2504-8. doi: 10.1016/j.bmcl.2009.03.034. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19349179
Mapping the kinase domain of Janus Kinase 3.
Adams C, Aldous DJ, Amendola S, Bamborough P, Bright C, Crowe S, Eastwood P, Fenton G, Foster M, Harrison TK, King S, Lai J, Lawrence C, Letallec JP, McCarthy C, Moorcroft N, Page K, Rao S, Redford J, Sadiq S, Smith K, Souness JE, Thurairatnam S, Vine M, Wyman B. Adams C, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3105-10. doi: 10.1016/s0960-894x(03)00657-7. Bioorg Med Chem Lett. 2003. PMID: 12941344
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
Lai JY, Cox PJ, Patel R, Sadiq S, Aldous DJ, Thurairatnam S, Smith K, Wheeler D, Jagpal S, Parveen S, Fenton G, Harrison TK, McCarthy C, Bamborough P. Lai JY, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3111-4. doi: 10.1016/s0960-894x(03)00658-9. Bioorg Med Chem Lett. 2003. PMID: 12941345
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases.
Christopher JA, Avitabile BG, Bamborough P, Champigny AC, Cutler GJ, Dyos SL, Grace KG, Kerns JK, Kitson JD, Mellor GW, Morey JV, Morse MA, O'Malley CF, Patel CB, Probst N, Rumsey W, Smith CA, Wilson MJ. Christopher JA, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3972-7. doi: 10.1016/j.bmcl.2007.04.088. Epub 2007 Apr 29. Bioorg Med Chem Lett. 2007. PMID: 17502144
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Bamborough P, Angell RM, Bhamra I, Brown D, Bull J, Christopher JA, Cooper AW, Fazal LH, Giordano I, Hind L, Patel VK, Ranshaw LE, Sims MJ, Skone PA, Smith KJ, Vickerstaff E, Washington M. Bamborough P, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. doi: 10.1016/j.bmcl.2007.04.029. Epub 2007 Apr 13. Bioorg Med Chem Lett. 2007. PMID: 17600705
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.
Angell RM, Angell TD, Bamborough P, Brown D, Brown M, Buckton JB, Cockerill SG, Edwards CD, Jones KL, Longstaff T, Smee PA, Smith KJ, Somers DO, Walker AL, Willson M. Angell RM, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8. doi: 10.1016/j.bmcl.2007.10.043. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 17981461
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL. Angell RM, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. doi: 10.1016/j.bmcl.2007.10.076. Epub 2007 Nov 19. Bioorg Med Chem Lett. 2008. PMID: 18006306
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Angell RM, Angell TD, Bamborough P, Bamford MJ, Chung CW, Cockerill SG, Flack SS, Jones KL, Laine DI, Longstaff T, Ludbrook S, Pearson R, Smith KJ, Smee PA, Somers DO, Walker AL. Angell RM, et al. Among authors: bamborough p. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. doi: 10.1016/j.bmcl.2008.06.028. Epub 2008 Jun 12. Bioorg Med Chem Lett. 2008. PMID: 18602262
82 results