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Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
Boshoff HIM, Young K, Ahn YM, Yadav VD, Crowley BM, Yang L, Su J, Oh S, Arora K, Andrews J, Manikkam M, Sutphin M, Smith AJ, Weiner DM, Piazza MK, Fleegle JD, Gomez F, Dayao EK, Prideaux B, Zimmerman M, Kaya F, Sarathy J, Tan VY, Via LE, Tschirret-Guth R, Lenaerts AJ, Robertson GT, Dartois V, Olsen DB, Barry CE 3rd. Boshoff HIM, et al. Among authors: barry ce 3rd. ACS Infect Dis. 2024 Apr 6. doi: 10.1021/acsinfecdis.4c00025. Online ahead of print. ACS Infect Dis. 2024. PMID: 38581700
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, Xu L, Barry CE 3rd, Jain RK. Datta M, et al. Among authors: barry ce 3rd. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2321336121. doi: 10.1073/pnas.2321336121. Epub 2024 Mar 26. Proc Natl Acad Sci U S A. 2024. PMID: 38530888 Free PMC article.
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial.
Diacon AH, Barry CE 3rd, Carlton A, Chen RY, Davies M, de Jager V, Fletcher K, Koh GCKW, Kontsevaya I, Heyckendorf J, Lange C, Reimann M, Penman SL, Scott R, Maher-Edwards G, Tiberi S, Vlasakakis G, Upton CM, Aguirre DB. Diacon AH, et al. Among authors: barry ce 3rd. Nat Med. 2024 Mar;30(3):896-904. doi: 10.1038/s41591-024-02829-7. Epub 2024 Feb 16. Nat Med. 2024. PMID: 38365949 Free PMC article. Clinical Trial.
High resolution imaging and five-year tuberculosis contact outcomes.
Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR Jr, Salgame P, Alland D, Barry CE 3rd, Flynn JL, Ellner JJ, Wilkinson RJ. Esmail H, et al. Among authors: barry ce 3rd. medRxiv [Preprint]. 2023 Jul 3:2023.07.03.23292111. doi: 10.1101/2023.07.03.23292111. medRxiv. 2023. PMID: 37461515 Free PMC article. Preprint.
Distributable, Metabolic PET Reporting of Tuberculosis.
Naseer Khan RM, Ahn YM, Marriner GA, Via LE, D'Hooge F, Lee SS, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, Dayao E, Piazza MK, Gomez F, Dieckmann W, Herscovitch P, Mason NS, Swenson R, Kiesewetter DO, Backus KM, Geng Y, Raj R, Anthony DC, Flynn JL, Barry CE 3rd, Davis BG. Naseer Khan RM, et al. Among authors: barry ce 3rd. bioRxiv [Preprint]. 2023 Apr 3:2023.04.03.535218. doi: 10.1101/2023.04.03.535218. bioRxiv. 2023. PMID: 37333343 Free PMC article. Preprint.
Chemical approaches to unraveling the biology of mycobacteria.
Finin P, Khan RMN, Oh S, Boshoff HIM, Barry CE 3rd. Finin P, et al. Among authors: barry ce 3rd. Cell Chem Biol. 2023 May 18;30(5):420-435. doi: 10.1016/j.chembiol.2023.04.014. Cell Chem Biol. 2023. PMID: 37207631 Review.
275 results