Beaulieu PL - Search Results

1

Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.

Beaulieu PL. Beaulieu PL. Expert Opin Ther Pat. 2009 Feb;19(2):145-64. doi: 10.1517/13543770802672598. Expert Opin Ther Pat. 2009. PMID: 19441916 Review.

2

Finger loop inhibitors of the HCV NS5B polymerase: discovery and prospects for new HCV therapy.

Beaulieu PL. Beaulieu PL. Curr Opin Drug Discov Devel. 2006 Sep;9(5):618-26. Curr Opin Drug Discov Devel. 2006. PMID: 17002222 Review.

3

Inhibitors of the HCV NS5B polymerase: new hope for the treatment of hepatitis C infections.

Beaulieu PL, Tsantrizos YS. Beaulieu PL, et al. Curr Opin Investig Drugs. 2004 Aug;5(8):838-50. Curr Opin Investig Drugs. 2004. PMID: 15600240 Review.

4

The discovery of finger loop inhibitors of the hepatitis C virus NS5B polymerase: status and prospects for novel HCV therapeutics.

Beaulieu PL. Beaulieu PL. IDrugs. 2006 Jan;9(1):39-43. IDrugs. 2006. PMID: 16374732 Review.

5

Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.

Beaulieu PL. Beaulieu PL. Curr Opin Investig Drugs. 2007 Aug;8(8):614-34. Curr Opin Investig Drugs. 2007. PMID: 17668364 Review.

6

Filibuvir, a non-nucleoside NS5B polymerase inhibitor for the potential oral treatment of chronic HCV infection.

Beaulieu PL. Beaulieu PL. IDrugs. 2010 Dec;13(12):938-48. IDrugs. 2010. PMID: 21154154 Review.

7

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Beaulieu PL, Bös M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, Gillard J, Goulet S, McKercher G, Poupart MA, Valois S, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):967-71. doi: 10.1016/j.bmcl.2003.12.032. Bioorg Med Chem Lett. 2004. PMID: 15013003

8

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24. doi: 10.1016/j.bmcl.2003.10.023. Bioorg Med Chem Lett. 2004. PMID: 14684311

9

Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.

Kukolj G, McGibbon GA, McKercher G, Marquis M, Lefèbvre S, Thauvette L, Gauthier J, Goulet S, Poupart MA, Beaulieu PL. Kukolj G, et al. Among authors: beaulieu pl. J Biol Chem. 2005 Nov 25;280(47):39260-7. doi: 10.1074/jbc.M506407200. Epub 2005 Sep 27. J Biol Chem. 2005. PMID: 16188890 Free article.

10

Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C virus (HCV).

Beaulieu PL, Bös M, Cordingley MG, Chabot C, Fazal G, Garneau M, Gillard JR, Jolicoeur E, LaPlante S, McKercher G, Poirier M, Poupart MA, Tsantrizos YS, Duan J, Kukolj G. Beaulieu PL, et al. J Med Chem. 2012 Sep 13;55(17):7650-66. doi: 10.1021/jm3006788. Epub 2012 Aug 16. J Med Chem. 2012. PMID: 22849725

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