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Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.
Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A. Hirao M, et al. Among authors: bedalov a. J Biol Chem. 2003 Dec 26;278(52):52773-82. doi: 10.1074/jbc.M308966200. Epub 2003 Oct 8. J Biol Chem. 2003. PMID: 14534292 Free article.
The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov, A., Gatbonton, T., Irvine, W. P., Gottschling, D. E., and Simon, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 15 …
The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov …
Identification of a small molecule inhibitor of Sir2p.
Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8. doi: 10.1073/pnas.261574398. Proc Natl Acad Sci U S A. 2001. PMID: 11752457 Free PMC article.
Sir2 flexes its muscle.
Bedalov A, Simon JA. Bedalov A, et al. Dev Cell. 2003 Aug;5(2):188-9. doi: 10.1016/s1534-5807(03)00237-5. Dev Cell. 2003. PMID: 12919668 Free article.
Inhibitors of Sir2: evaluation of splitomicin analogues.
Posakony J, Hirao M, Stevens S, Simon JA, Bedalov A. Posakony J, et al. Among authors: bedalov a. J Med Chem. 2004 May 6;47(10):2635-44. doi: 10.1021/jm030473r. J Med Chem. 2004. PMID: 15115404
Yeast as a model system for anticancer drug discovery.
Simon JA, Bedalov A. Simon JA, et al. Among authors: bedalov a. Nat Rev Cancer. 2004 Jun;4(6):481-92. doi: 10.1038/nrc1372. Nat Rev Cancer. 2004. PMID: 15170450 Review. No abstract available.
Neuroscience. NAD to the rescue.
Bedalov A, Simon JA. Bedalov A, et al. Science. 2004 Aug 13;305(5686):954-5. doi: 10.1126/science.1102497. Science. 2004. PMID: 15310883 No abstract available.
Substrate-specific activation of sirtuins by resveratrol.
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Kaeberlein M, et al. Among authors: bedalov a. J Biol Chem. 2005 Apr 29;280(17):17038-45. doi: 10.1074/jbc.M500655200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684413 Free article.
71 results