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Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.
El-Remessy AB, Behzadian MA, Abou-Mohamed G, Franklin T, Caldwell RW, Caldwell RB. El-Remessy AB, et al. Among authors: behzadian ma. Am J Pathol. 2003 Jun;162(6):1995-2004. doi: 10.1016/S0002-9440(10)64332-5. Am J Pathol. 2003. PMID: 12759255 Free PMC article.
VEGF-induced permeability increase is mediated by caveolae.
Feng Y, Venema VJ, Venema RC, Tsai N, Behzadian MA, Caldwell RB. Feng Y, et al. Among authors: behzadian ma. Invest Ophthalmol Vis Sci. 1999 Jan;40(1):157-67. Invest Ophthalmol Vis Sci. 1999. PMID: 9888439
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