Control of tumor angiogenesis and metastasis through modulation of cell redox state

José J Serrano; Belén Delgado; Miguel Ángel Medina

doi:10.1016/j.bbcan.2020.188352

Control of tumor angiogenesis and metastasis through modulation of cell redox state

Biochim Biophys Acta Rev Cancer. 2020 Apr;1873(2):188352. doi: 10.1016/j.bbcan.2020.188352. Epub 2020 Feb 5.

Authors

José J Serrano¹, Belén Delgado¹, Miguel Ángel Medina²

Affiliations

¹ Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain.
² Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga, Spain. Electronic address: medina@uma.es.

PMID: 32035101
DOI: 10.1016/j.bbcan.2020.188352

Abstract

Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the connections between redox and cancer. There is ample evidence of the involvement of cellular redox state on the different hallmarks of cancer. Evidence of the control of tumor angiogenesis and metastasis through modulation of cell redox state is reviewed and highlighted.

Keywords: Metastasis; Redox metabolism; Redox signaling; Tumor angiogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Disease Progression
Humans
Neoplasms / blood supply
Neoplasms / metabolism
Neoplasms / pathology*
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / pathology*
Oxidation-Reduction*
Signal Transduction