Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet⁺ B cells

Affiliations

• ¹ Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. kcsomos@usf.edu.
• ² Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
• ³ Department of Pediatrics, University of Szeged, Szeged, Hungary.
• ⁴ Cancer and Blood Disorders Institute and Department of Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
• ⁵ Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ⁶ Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, USA.
• ⁷ Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
• ⁸ Department of Pathology & Laboratory Medicine, Johns Hopkins All Children's Hospital, St Petersburg, FL, USA.
• ⁹ Eurofins Viracor Laboratories, Lee Summit's, MO, USA.
• ¹⁰ Immunology Outpatient Clinic, Vienna, Austria.
• ¹¹ Belarusian Research Center for Pediatric Oncology, Minsk, Belarus.
• ¹² Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
• ¹³ Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
• ¹⁴ Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
• ¹⁵ Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
• ¹⁶ Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
• ¹⁷ Allergy Immunology Division, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
• ¹⁸ Institute for Immunology, the University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁹ Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA.
• ²⁰ Deptartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
• ²¹ Department of Clinical Immunology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria.
• ²² Department of Immunology, Second Faculty of Medicine Charles University and University Hospital Motol, Prague, Czech Republic.
• ²³ Université de Paris, Paris, France.
• ²⁴ Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades Université Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
• ²⁵ Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Institut Imagine, Paris, France.
• ²⁶ Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR1163, Institut Imagine, Paris, France.
• ²⁷ Windom Allergy, Asthma and Sinus, Sarasota, FL, USA.
• ²⁸ Department of Immunology and Allergy, Sheffield Teaching Hospitals, Sheffield, UK.
• ²⁹ Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK.
• ³⁰ National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK.
• ³¹ Division of Allergy, Immunology and Pulmonary Medicine, Duke University School of Medicine, Durham, NC, USA.
• ³² Cancer and Blood Disorder Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
• ³³ Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA.
• ³⁴ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
• ³⁵ Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics and Jeffrey Modell Diagnostic and Research Center, University of California, Los Angeles, Los Angeles, CA, USA.
• ³⁶ Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
• ³⁷ Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of technology and Harvard University, Cambridge, MA, USA.
• ³⁸ Department of Immunobiology, Yale University, New Haven, CT, USA.
• ³⁹ Section of Rheumatology, Allergy and Clinical Immunology, Yale School of Medicine, New Haven, CT, USA.
• ⁴⁰ Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. jolanwalter@usf.edu.
• ⁴¹ Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. jolanwalter@usf.edu.