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Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity.
Puig T, Turrado C, Benhamú B, Aguilar H, Relat J, Ortega-Gutiérrez S, Casals G, Marrero PF, Urruticoechea A, Haro D, López-Rodríguez ML, Colomer R. Puig T, et al. Among authors: benhamu b. Clin Cancer Res. 2009 Dec 15;15(24):7608-7615. doi: 10.1158/1078-0432.CCR-09-0856. Clin Cancer Res. 2009. PMID: 20008854
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Puig T, Aguilar H, Cufí S, Oliveras G, Turrado C, Ortega-Gutiérrez S, Benhamú B, López-Rodríguez ML, Urruticoechea A, Colomer R. Puig T, et al. Among authors: benhamu b. Breast Cancer Res. 2011;13(6):R131. doi: 10.1186/bcr3077. Epub 2011 Dec 16. Breast Cancer Res. 2011. PMID: 22177475 Free PMC article.
New synthetic inhibitors of fatty acid synthase with anticancer activity.
Turrado C, Puig T, García-Cárceles J, Artola M, Benhamú B, Ortega-Gutiérrez S, Relat J, Oliveras G, Blancafort A, Haro D, Marrero PF, Colomer R, López-Rodríguez ML. Turrado C, et al. Among authors: benhamu b. J Med Chem. 2012 Jun 14;55(11):5013-23. doi: 10.1021/jm2016045. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559865
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Veigel D, Wagner R, Stübiger G, Wuczkowski M, Filipits M, Horvat R, Benhamú B, López-Rodríguez ML, Leisser A, Valent P, Grusch M, Hegardt FG, García J, Serra D, Auersperg N, Colomer R, Grunt TW. Veigel D, et al. Among authors: benhamu b. Int J Cancer. 2015 May 1;136(9):2078-90. doi: 10.1002/ijc.29261. Epub 2014 Nov 3. Int J Cancer. 2015. PMID: 25302649 Free article.
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Wagner R, Stübiger G, Veigel D, Wuczkowski M, Lanzerstorfer P, Weghuber J, Karteris E, Nowikovsky K, Wilfinger-Lutz N, Singer CF, Colomer R, Benhamú B, López-Rodríguez ML, Valent P, Grunt TW. Wagner R, et al. Among authors: benhamu b. Oncotarget. 2017 Feb 14;8(7):11600-11613. doi: 10.18632/oncotarget.14591. Oncotarget. 2017. PMID: 28086243 Free PMC article.
Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.
Orcajo-Rincón ÁL, Ortega-Gutiérrez S, Serrano P, Torrecillas IR, Wüthrich K, Campillo M, Pardo L, Viso A, Benhamú B, López-Rodríguez ML. Orcajo-Rincón ÁL, et al. Among authors: benhamu b. J Med Chem. 2011 Feb 24;54(4):1096-100. doi: 10.1021/jm101478n. Epub 2011 Jan 27. J Med Chem. 2011. PMID: 21271718
Development of molecular probes for the human 5-HT(6) receptor.
Vázquez-Villa H, González-Vera JA, Benhamú B, Viso A, Fernández de la Pradilla R, Junquera E, Aicart E, López-Rodríguez ML, Ortega-Gutiérrez S. Vázquez-Villa H, et al. Among authors: benhamu b. J Med Chem. 2010 Oct 14;53(19):7095-106. doi: 10.1021/jm1007177. J Med Chem. 2010. PMID: 20845907
New Trends in Aging Drug Discovery.
Benhamú B, Martín-Fontecha M, Vázquez-Villa H, López-Rodríguez ML, Ortega-Gutiérrez S. Benhamú B, et al. Biomedicines. 2022 Aug 18;10(8):2006. doi: 10.3390/biomedicines10082006. Biomedicines. 2022. PMID: 36009552 Free PMC article. Review.
45 results