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Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site.
Sanders MJ, Ratinaud Y, Neopane K, Bonhoure N, Day EA, Ciclet O, Lassueur S, Naranjo Pinta M, Deak M, Brinon B, Christen S, Steinberg GR, Barron D, Sakamoto K. Sanders MJ, et al. Among authors: brinon b. J Biol Chem. 2022 May;298(5):101852. doi: 10.1016/j.jbc.2022.101852. Epub 2022 Mar 21. J Biol Chem. 2022. PMID: 35331736 Free PMC article.
Cardiac commitment of primate embryonic stem cells.
Leschik J, Stefanovic S, Brinon B, Pucéat M. Leschik J, et al. Among authors: brinon b. Nat Protoc. 2008;3(9):1381-7. doi: 10.1038/nprot.2008.116. Nat Protoc. 2008. PMID: 18772864
Pluripotent Stem Cell-Based Drug Screening Reveals Cardiac Glycosides as Modulators of Myotonic Dystrophy Type 1.
Maury Y, Poydenot P, Brinon B, Lesueur L, Gide J, Roquevière S, Côme J, Polvèche H, Auboeuf D, Alexandre Denis J, Pietu G, Furling D, Lechuga M, Baghdoyan S, Peschanski M, Martinat C. Maury Y, et al. Among authors: brinon b. iScience. 2019 Jan 25;11:258-271. doi: 10.1016/j.isci.2018.12.019. Epub 2018 Dec 27. iScience. 2019. PMID: 30639849 Free PMC article.
High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.
Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Aurégan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL. Charbord J, et al. Among authors: brinon b. Stem Cells. 2013 Sep;31(9):1816-28. doi: 10.1002/stem.1430. Stem Cells. 2013. PMID: 23712629
A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.
Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, Binder P, Hagège A, Desnos M, Renaud JF, Menasché P, Pucéat M. Blin G, et al. Among authors: brinon b. J Clin Invest. 2010 Apr;120(4):1125-39. doi: 10.1172/JCI40120. Epub 2010 Mar 24. J Clin Invest. 2010. PMID: 20335662 Free PMC article.
Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells.
Bel A, Planat-Bernard V, Saito A, Bonnevie L, Bellamy V, Sabbah L, Bellabas L, Brinon B, Vanneaux V, Pradeau P, Peyrard S, Larghero J, Pouly J, Binder P, Garcia S, Shimizu T, Sawa Y, Okano T, Bruneval P, Desnos M, Hagège AA, Casteilla L, Pucéat M, Menasché P. Bel A, et al. Among authors: brinon b. Circulation. 2010 Sep 14;122(11 Suppl):S118-23. doi: 10.1161/CIRCULATIONAHA.109.927293. Circulation. 2010. PMID: 20837902