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Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.
Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B. Castillo SD, et al. Among authors: berenjeno im. Sci Transl Med. 2016 Mar 30;8(332):332ra43. doi: 10.1126/scitranslmed.aad9982. Sci Transl Med. 2016. PMID: 27030595 Free PMC article.
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B. Berenjeno IM, et al. Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4. Nat Commun. 2017. PMID: 29170395 Free PMC article.
PI3K regulatory subunits lose control in cancer.
Berenjeno IM, Vanhaesebroeck B. Berenjeno IM, et al. Cancer Cell. 2009 Dec 8;16(6):449-50. doi: 10.1016/j.ccr.2009.11.017. Cancer Cell. 2009. PMID: 19962660 Free article.
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V, Vanhaesebroeck B. Aksoy E, et al. Among authors: berenjeno im. Nat Immunol. 2012 Nov;13(11):1045-1054. doi: 10.1038/ni.2426. Epub 2012 Sep 30. Nat Immunol. 2012. PMID: 23023391 Free PMC article.
Transcriptomal profiling of site-specific Ras signals.
Agudo-Ibáñez L, Núñez F, Calvo F, Berenjeno IM, Bustelo XR, Crespo P. Agudo-Ibáñez L, et al. Among authors: berenjeno im. Cell Signal. 2007 Nov;19(11):2264-76. doi: 10.1016/j.cellsig.2007.06.025. Epub 2007 Jul 4. Cell Signal. 2007. PMID: 17714917 Free PMC article.
13 results