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Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.
Bernardi P, Vassanelli S, Veronese P, Colonna R, Szabó I, Zoratti M. Bernardi P, et al. J Biol Chem. 1992 Feb 15;267(5):2934-9. J Biol Chem. 1992. PMID: 1737749 Free article.
Since PhAsO induces the PTP even in the presence of excess EGTA and in the absence of respiration (Lenartowicz, E., Bernardi, P., and Azzone, G.F. (1991) J. Bioenerg. Biomembr. 23, 679-688), we have been able to study the Ca2+ dependence of the induction process. .. …
Since PhAsO induces the PTP even in the presence of excess EGTA and in the absence of respiration (Lenartowicz, E., Bernardi, P …
Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A.
Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P. Petronilli V, et al. Among authors: bernardi p. Biochim Biophys Acta. 1994 Aug 30;1187(2):255-9. doi: 10.1016/0005-2728(94)90122-8. Biochim Biophys Acta. 1994. PMID: 7521212
Many physiological and pathological effectors, including Ca2+ and ADP, modulate MTP operation directly through changes of the gating potential rather than indirectly through changes of the membrane potential (Petronilli, V., Cola, C., Massari, S., Colonna, R. and Bernardi, …
Many physiological and pathological effectors, including Ca2+ and ADP, modulate MTP operation directly through changes of the gating potenti …
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.
Petronilli V, Cola C, Bernardi P. Petronilli V, et al. Among authors: bernardi p. J Biol Chem. 1993 Jan 15;268(2):1011-6. J Biol Chem. 1993. PMID: 7678245 Free article.
Energized rat liver mitochondria incubated in sucrose medium take up a Ca2+ pulse but do not show activation of the MTP upon addition of fully uncoupling concentrations of carbonyl cyanide-p-trifluoromethoxy-phenyl hydrazone (FCCP). Yet, addition of ruthenium red immediate …
Energized rat liver mitochondria incubated in sucrose medium take up a Ca2+ pulse but do not show activation of the MTP upon addition of ful …
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation.
Nicolli A, Petronilli V, Bernardi P. Nicolli A, et al. Among authors: bernardi p. Biochemistry. 1993 Apr 27;32(16):4461-5. doi: 10.1021/bi00067a039. Biochemistry. 1993. PMID: 7682848
This is due to locking of the pore in the closed conformation by matrix acidification and fast Ca2+ efflux following membrane depolarization (Petronilli, V., Cola, C., & Bernardi P. (1993) J. Biol. Chem. 268, 1011-1016). Here we show that addition of diethyl pyr …
This is due to locking of the pore in the closed conformation by matrix acidification and fast Ca2+ efflux following membrane depolarization …
524 results