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The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.
Neri A, Marmiroli S, Tassone P, Lombardi L, Nobili L, Verdelli D, Civallero M, Cosenza M, Bertacchini J, Federico M, De Pol A, Deliliers GL, Sacchi S. Neri A, et al. Among authors: bertacchini j. Leuk Lymphoma. 2008 Jul;49(7):1374-83. doi: 10.1080/10428190802078289. Leuk Lymphoma. 2008. PMID: 18452078
Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis.
Bertacchini J, Guida M, Accordi B, Mediani L, Martelli AM, Barozzi P, Petricoin E 3rd, Liotta L, Milani G, Giordan M, Luppi M, Forghieri F, De Pol A, Cocco L, Basso G, Marmiroli S. Bertacchini J, et al. Leukemia. 2014 Nov;28(11):2197-205. doi: 10.1038/leu.2014.123. Epub 2014 Apr 4. Leukemia. 2014. PMID: 24699302
A-type lamins and signaling: the PI 3-kinase/Akt pathway moves forward.
Marmiroli S, Bertacchini J, Beretti F, Cenni V, Guida M, De Pol A, Maraldi NM, Lattanzi G. Marmiroli S, et al. Among authors: bertacchini j. J Cell Physiol. 2009 Sep;220(3):553-61. doi: 10.1002/jcp.21807. J Cell Physiol. 2009. PMID: 19479937 Review.
Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.
Mediani L, Gibellini F, Bertacchini J, Frasson C, Bosco R, Accordi B, Basso G, Bonora M, Calabrò ML, Mattiolo A, Sgarbi G, Baracca A, Pinton P, Riva G, Rampazzo E, Petrizza L, Prodi L, Milani D, Luppi M, Potenza L, De Pol A, Cocco L, Capitani S, Marmiroli S. Mediani L, et al. Among authors: bertacchini j. Oncotarget. 2016 Feb 2;7(5):5521-37. doi: 10.18632/oncotarget.6315. Oncotarget. 2016. PMID: 26575168 Free PMC article.
Cross-talk between the CK2 and AKT signaling pathways in cancer.
Ruzzene M, Bertacchini J, Toker A, Marmiroli S. Ruzzene M, et al. Among authors: bertacchini j. Adv Biol Regul. 2017 May;64:1-8. doi: 10.1016/j.jbior.2017.03.002. Epub 2017 Mar 28. Adv Biol Regul. 2017. PMID: 28373060 Review.
Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells.
Cenni V, Bertacchini J, Beretti F, Lattanzi G, Bavelloni A, Riccio M, Ruzzene M, Marin O, Arrigoni G, Parnaik V, Wehnert M, Maraldi NM, de Pol A, Cocco L, Marmiroli S. Cenni V, et al. Among authors: bertacchini j. J Proteome Res. 2008 Nov;7(11):4727-35. doi: 10.1021/pr800262g. Epub 2008 Sep 23. J Proteome Res. 2008. PMID: 18808171
Dual inhibition of PI3K/mTOR signaling in chemoresistant AML primary cells.
Bertacchini J, Frasson C, Chiarini F, D'Avella D, Accordi B, Anselmi L, Barozzi P, Forghieri F, Luppi M, Martelli AM, Basso G, Najmaldin S, Khosravi A, Rahim F, Marmiroli S. Bertacchini J, et al. Adv Biol Regul. 2018 May;68:2-9. doi: 10.1016/j.jbior.2018.03.001. Epub 2018 Mar 19. Adv Biol Regul. 2018. PMID: 29576448
46 results