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RXR is an essential component of the oncogenic PML/RARA complex in vivo.
Zhu J, Nasr R, Pérès L, Riaucoux-Lormière F, Honoré N, Berthier C, Kamashev D, Zhou J, Vitoux D, Lavau C, de Thé H. Zhu J, et al. Among authors: berthier c. Cancer Cell. 2007 Jul;12(1):23-35. doi: 10.1016/j.ccr.2007.06.004. Cancer Cell. 2007. PMID: 17613434 Free article.
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, Lallemand-Breitenbach V, Gourmel B, Vitoux D, Pandolfi PP, Rochette-Egly C, Zhu J, de Thé H. Nasr R, et al. Among authors: berthier c. Nat Med. 2008 Dec;14(12):1333-42. doi: 10.1038/nm.1891. Epub 2008 Nov 23. Nat Med. 2008. PMID: 19029980
Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells.
El Hajj H, Dassouki Z, Berthier C, Raffoux E, Ades L, Legrand O, Hleihel R, Sahin U, Tawil N, Salameh A, Zibara K, Darwiche N, Mohty M, Dombret H, Fenaux P, de Thé H, Bazarbachi A. El Hajj H, et al. Among authors: berthier c. Blood. 2015 May 28;125(22):3447-54. doi: 10.1182/blood-2014-11-612416. Epub 2015 Mar 23. Blood. 2015. PMID: 25800051 Free article.
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.
Lehmann-Che J, Bally C, Letouzé E, Berthier C, Yuan H, Jollivet F, Ades L, Cassinat B, Hirsch P, Pigneux A, Mozziconacci MJ, Kogan S, Fenaux P, de Thé H. Lehmann-Che J, et al. Among authors: berthier c. Nat Commun. 2018 May 24;9(1):2047. doi: 10.1038/s41467-018-04384-5. Nat Commun. 2018. PMID: 29795382 Free PMC article.
A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c acute myeloid leukemia.
Hleihel R, El Hajj H, Wu HC, Berthier C, Zhu HH, Massoud R, Chakhachiro Z, El Sabban M, De The H, Bazarbachi A. Hleihel R, et al. Among authors: berthier c. Haematologica. 2021 Dec 1;106(12):3090-3099. doi: 10.3324/haematol.2020.274878. Haematologica. 2021. PMID: 34047175 Free PMC article.
Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.
Wu HC, Rérolle D, Berthier C, Hleihel R, Sakamoto T, Quentin S, Benhenda S, Morganti C, Wu C, Conte L, Rimsky S, Sebert M, Clappier E, Souquere S, Gachet S, Soulier J, Durand S, Trowbridge JJ, Bénit P, Rustin P, El Hajj H, Raffoux E, Ades L, Itzykson R, Dombret H, Fenaux P, Espeli O, Kroemer G, Brunetti L, Mak TW, Lallemand-Breitenbach V, Bazarbachi A, Falini B, Ito K, Martelli MP, de Thé H. Wu HC, et al. Among authors: berthier c. Cancer Discov. 2021 Dec 1;11(12):3198-3213. doi: 10.1158/2159-8290.CD-21-0177. Cancer Discov. 2021. PMID: 34301789 Free PMC article.
209 results