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Interleukin-34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony-Stimulating Factor Receptor.
Van Raemdonck K, Umar S, Palasiewicz K, Volin MV, Elshabrawy HA, Romay B, Tetali C, Ahmed A, Amin MA, Zomorrodi RK, Sweiss N, Shahrara S. Van Raemdonck K, et al. Among authors: romay b. Arthritis Rheumatol. 2021 Nov;73(11):2003-2014. doi: 10.1002/art.41792. Epub 2021 Sep 22. Arthritis Rheumatol. 2021. PMID: 33982895 Free PMC article.
Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types.
Umar S, Palasiewicz K, Volin MV, Romay B, Rahat R, Tetali C, Arami S, Guma M, Ascoli C, Sweiss N, Zomorrodi RK, O'Neill LAJ, Shahrara S. Umar S, et al. Among authors: romay b. Cell Mol Life Sci. 2021 Dec;78(23):7693-7707. doi: 10.1007/s00018-021-03978-5. Epub 2021 Oct 27. Cell Mol Life Sci. 2021. PMID: 34705053 Free PMC article.
IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion.
Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Amin MA, Zomorrodi RK, Arami S, Gonzalez M, Rao V, Zanotti B, Fox DA, Sweiss N, Shahrara S. Umar S, et al. Among authors: romay b. Cell Mol Immunol. 2021 Sep;18(9):2199-2210. doi: 10.1038/s41423-020-0433-8. Epub 2020 May 15. Cell Mol Immunol. 2021. PMID: 32415262 Free PMC article.