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2020 17
2021 38
2022 23
2023 10
2024 2

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86 results

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Evolution of antibody immunity to SARS-CoV-2.
Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, Hägglöf T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC. Gaebler C, et al. Among authors: bieniasz pd. Nature. 2021 Mar;591(7851):639-644. doi: 10.1038/s41586-021-03207-w. Epub 2021 Jan 18. Nature. 2021. PMID: 33461210 Free PMC article.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. ...Here we report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 mon …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for …
Replication and single-cycle delivery of SARS-CoV-2 replicons.
Ricardo-Lax I, Luna JM, Thao TTN, Le Pen J, Yu Y, Hoffmann HH, Schneider WM, Razooky BS, Fernandez-Martinez J, Schmidt F, Weisblum Y, Trüeb BS, Berenguer Veiga I, Schmied K, Ebert N, Michailidis E, Peace A, Sánchez-Rivera FJ, Lowe SW, Rout MP, Hatziioannou T, Bieniasz PD, Poirier JT, MacDonald MR, Thiel V, Rice CM. Ricardo-Lax I, et al. Among authors: bieniasz pd. Science. 2021 Nov 26;374(6571):1099-1106. doi: 10.1126/science.abj8430. Epub 2021 Oct 14. Science. 2021. PMID: 34648371 Free PMC article.
Molecular virology tools are critical for basic studies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental systems that do not rely on viruses capable of spread are needed for potential use in …
Molecular virology tools are critical for basic studies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 …
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.
Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, Lorenzi JCC, Park S, Schmidt F, Wang Z, Huang Y, Luo Y, Nair MS, Wang P, Schulz JE, Tessarollo L, Bylund T, Chuang GY, Olia AS, Stephens T, Teng IT, Tsybovsky Y, Zhou T, Munster V, Ho DD, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Kwong PD, Casellas R. Xu J, et al. Among authors: bieniasz pd. Nature. 2021 Jul;595(7866):278-282. doi: 10.1038/s41586-021-03676-z. Epub 2021 Jun 7. Nature. 2021. PMID: 34098567 Free PMC article.
Group 2 is almost exclusively focused to the RBD-ACE2 interface and does not neutralize SARS-CoV-2 variants that carry E484K or N501Y substitutions. However, nanobodies in group 2 retain full neutralization activity against these variants when expressed as ho …
Group 2 is almost exclusively focused to the RBD-ACE2 interface and does not neutralize SARS-CoV-2 variants that carry …
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
Schaefer-Babajew D, Wang Z, Muecksch F, Cho A, Loewe M, Cipolla M, Raspe R, Johnson B, Canis M, DaSilva J, Ramos V, Turroja M, Millard KG, Schmidt F, Witte L, Dizon J, Shimeliovich I, Yao KH, Oliveira TY, Gazumyan A, Gaebler C, Bieniasz PD, Hatziioannou T, Caskey M, Nussenzweig MC. Schaefer-Babajew D, et al. Among authors: bieniasz pd. Nature. 2023 Jan;613(7945):735-742. doi: 10.1038/s41586-022-05609-w. Epub 2022 Dec 6. Nature. 2023. PMID: 36473496 Free PMC article.
Here we examined the memory B cell response in individuals who received two high-affinity anti-SARS-CoV-2 monoclonal antibodies and subsequently two doses of an mRNA vaccine(4-8). ...
Here we examined the memory B cell response in individuals who received two high-affinity anti-SARS-CoV-2 monoclonal an …
SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity.
Zhang F, Schmidt F, Muecksch F, Wang Z, Gazumyan A, Nussenzweig MC, Gaebler C, Caskey M, Hatziioannou T, Bieniasz PD. Zhang F, et al. Among authors: bieniasz pd. bioRxiv [Preprint]. 2023 Jun 30:2023.06.30.547241. doi: 10.1101/2023.06.30.547241. bioRxiv. 2023. PMID: 37425700 Free PMC article. Updated. Preprint.
The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 22 N-linked glycosylation sequons and 17 O-linked glycosites. Here, we investigated the effect of individual glycosylation sites on SARS-CoV-2 …
The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 22 N-linked glycosy …
SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates.
Murphy EA, Guzman-Cardozo C, Sukhu AC, Parks DJ, Prabhu M, Mohammed I, Jurkiewicz M, Ketas TJ, Singh S, Canis M, Bednarski E, Hollingsworth A, Thompson EM, Eng D, Bieniasz PD, Riley LE, Hatziioannou T, Yang YJ. Murphy EA, et al. Among authors: bieniasz pd. Nat Commun. 2023 Aug 10;14(1):4598. doi: 10.1038/s41467-023-39989-y. Nat Commun. 2023. PMID: 37563124 Free PMC article.
We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV- …
We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without hist …
Molecular fate-mapping of serum antibody responses to repeat immunization.
Schiepers A, van 't Wout MFL, Greaney AJ, Zang T, Muramatsu H, Lin PJC, Tam YK, Mesin L, Starr TN, Bieniasz PD, Pardi N, Bloom JD, Victora GD. Schiepers A, et al. Among authors: bieniasz pd. Nature. 2023 Mar;615(7952):482-489. doi: 10.1038/s41586-023-05715-3. Epub 2023 Jan 16. Nature. 2023. PMID: 36646114 Free PMC article.
OAS-type suppression of new, variant-specific antibodies may pose a barrier to vaccination against rapidly evolving viruses such as influenza and SARS-CoV-2(6,7). Precise measurement of OAS-type suppression is challenging because cellular and temporal origins …
OAS-type suppression of new, variant-specific antibodies may pose a barrier to vaccination against rapidly evolving viruses such as influenz …
Predictors of Nonseroconversion after SARS-CoV-2 Infection.
Liu W, Russell RM, Bibollet-Ruche F, Skelly AN, Sherrill-Mix S, Freeman DA, Stoltz R, Lindemuth E, Lee FH, Sterrett S, Bar KJ, Erdmann N, Gouma S, Hensley SE, Ketas T, Cupo A, Cruz Portillo VM, Moore JP, Bieniasz PD, Hatziioannou T, Massey G, Minyard MB, Saag MS, Davis RS, Shaw GM, Britt WJ, Leal SM Jr, Goepfert P, Hahn BH. Liu W, et al. Among authors: bieniasz pd. Emerg Infect Dis. 2021 Sep;27(9):2454-2458. doi: 10.3201/eid2709.211042. Epub 2021 Jun 30. Emerg Infect Dis. 2021. PMID: 34193339 Free PMC article.
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2-specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription …
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS …
Enhanced SARS-CoV-2 neutralization by dimeric IgA.
Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Viant C, Gaebler C, Cipolla M, Hoffmann HH, Oliveira TY, Oren DA, Ramos V, Nogueira L, Michailidis E, Robbiani DF, Gazumyan A, Rice CM, Hatziioannou T, Bieniasz PD, Caskey M, Nussenzweig MC. Wang Z, et al. Among authors: bieniasz pd. Sci Transl Med. 2021 Jan 20;13(577):eabf1555. doi: 10.1126/scitranslmed.abf1555. Epub 2020 Dec 7. Sci Transl Med. 2021. PMID: 33288661 Free PMC article.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal surfaces. ...Thus, dimeric IgA responses may be particularly valuable for protection against SARS …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19) …
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.
De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magrì D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarström Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L. De Gasparo R, et al. Among authors: bieniasz pd. Nature. 2021 May;593(7859):424-428. doi: 10.1038/s41586-021-03461-y. Epub 2021 Mar 25. Nature. 2021. PMID: 33767445
Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein are among the most promising approaches against COVID-19(1,2). ...We also found that in a mouse model of SARS-CoV-2 infection with lung …
Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein are among the mos …
86 results