Bischoff F - Search Results

1

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. Lavreysen H, et al. Among authors: bischoff f. Mol Pharmacol. 2003 May;63(5):1082-93. doi: 10.1124/mol.63.5.1082. Mol Pharmacol. 2003. PMID: 12695537

2

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.

Kennis LE, Bischoff FP, Mertens CJ, Love CJ, Van den Keybus FA, Pieters S, Braeken M, Megens AA, Leysen JE. Kennis LE, et al. Among authors: bischoff fp. Bioorg Med Chem Lett. 2000 Jan 3;10(1):71-4. doi: 10.1016/s0960-894x(99)00591-0. Bioorg Med Chem Lett. 2000. PMID: 10636247

3

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.

Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L, Lesage AS. Lavreysen H, et al. Among authors: bischoff f. Neuropharmacology. 2004 Dec;47(7):961-72. doi: 10.1016/j.neuropharm.2004.08.007. Neuropharmacology. 2004. PMID: 15555631

4

Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.

Mabire D, Coupa S, Adelinet C, Poncelet A, Simonnet Y, Venet M, Wouters R, Lesage AS, Van Beijsterveldt L, Bischoff F. Mabire D, et al. Among authors: bischoff f. J Med Chem. 2005 Mar 24;48(6):2134-53. doi: 10.1021/jm049499o. J Med Chem. 2005. PMID: 15771457

5

A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone.

Huang Y, Narendran R, Bischoff F, Guo N, Zhu Z, Bae SA, Lesage AS, Laruelle M. Huang Y, et al. Among authors: bischoff f. J Med Chem. 2005 Aug 11;48(16):5096-9. doi: 10.1021/jm050263+. J Med Chem. 2005. PMID: 16078827

6

Synthesis and biodistribution of [11C]R107474, a new radiolabeled alpha2-adrenoceptor antagonist.

Van der Mey M, Windhorst AD, Klok RP, Herscheid JD, Kennis LE, Bischoff F, Bakker M, Langlois X, Heylen L, Jurzak M, Leysen JE. Van der Mey M, et al. Among authors: bischoff f. Bioorg Med Chem. 2006 Jul 1;14(13):4526-34. doi: 10.1016/j.bmc.2006.02.029. Epub 2006 Mar 6. Bioorg Med Chem. 2006. PMID: 16517171

7

Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor.

Huang Y, Narendran R, Bischoff F, Guo N, Bae SA, Hwang DR, Lesage AS, Laruelle M. Huang Y, et al. Among authors: bischoff f. Synapse. 2012 Dec;66(12):1002-14. doi: 10.1002/syn.21606. Epub 2012 Sep 29. Synapse. 2012. PMID: 22927303

8

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.

Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. Baxter EW, et al. Among authors: bischoff f. J Med Chem. 2007 Sep 6;50(18):4261-4. doi: 10.1021/jm0705408. Epub 2007 Aug 8. J Med Chem. 2007. PMID: 17685503

9

Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.

Madsen U, Bräuner-Osborne H, Frydenvang K, Hvene L, Johansen TN, Nielsen B, Sánchez C, Stensbøl TB, Bischoff F, Krogsgaard-Larsen P. Madsen U, et al. Among authors: bischoff f. J Med Chem. 2001 Mar 29;44(7):1051-9. doi: 10.1021/jm000441t. J Med Chem. 2001. PMID: 11297452

10

Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.

Bischoff F, Berthelot D, De Cleyn M, Macdonald G, Minne G, Oehlrich D, Pieters S, Surkyn M, Trabanco AA, Tresadern G, Van Brandt S, Velter I, Zaja M, Borghys H, Masungi C, Mercken M, Gijsen HJ. Bischoff F, et al. J Med Chem. 2012 Nov 8;55(21):9089-106. doi: 10.1021/jm201710f. Epub 2012 Jun 8. J Med Chem. 2012. PMID: 22650177

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