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De novo protein design enables the precise induction of RSV-neutralizing antibodies.
Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthésy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Más V, Ervin S, Eléouët JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE. Sesterhenn F, et al. Among authors: bonet j. Science. 2020 May 15;368(6492):eaay5051. doi: 10.1126/science.aay5051. Science. 2020. PMID: 32409444 Free PMC article.
Rosetta FunFolDes - A general framework for the computational design of functional proteins.
Bonet J, Wehrle S, Schriever K, Yang C, Billet A, Sesterhenn F, Scheck A, Sverrisson F, Veselkova B, Vollers S, Lourman R, Villard M, Rosset S, Krey T, Correia BE. Bonet J, et al. PLoS Comput Biol. 2018 Nov 19;14(11):e1006623. doi: 10.1371/journal.pcbi.1006623. eCollection 2018 Nov. PLoS Comput Biol. 2018. PMID: 30452434 Free PMC article.
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen.
Sesterhenn F, Galloux M, Vollers SS, Csepregi L, Yang C, Descamps D, Bonet J, Friedensohn S, Gainza P, Corthésy P, Chen M, Rosset S, Rameix-Welti MA, Éléouët JF, Reddy ST, Graham BS, Riffault S, Correia BE. Sesterhenn F, et al. Among authors: bonet j. PLoS Biol. 2019 Feb 21;17(2):e3000164. doi: 10.1371/journal.pbio.3000164. eCollection 2019 Feb. PLoS Biol. 2019. PMID: 30789898 Free PMC article.
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.
Giordano-Attianese G, Gainza P, Gray-Gaillard E, Cribioli E, Shui S, Kim S, Kwak MJ, Vollers S, Corria Osorio AJ, Reichenbach P, Bonet J, Oh BH, Irving M, Coukos G, Correia BE. Giordano-Attianese G, et al. Among authors: bonet j. Nat Biotechnol. 2020 Apr;38(4):426-432. doi: 10.1038/s41587-019-0403-9. Epub 2020 Feb 3. Nat Biotechnol. 2020. PMID: 32015549
Author Correction: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.
Giordano-Attianese G, Gainza P, Gray-Gaillard E, Cribioli E, Shui S, Kim S, Kwak MJ, Vollers S, Corria Osorio AJ, Reichenbach P, Bonet J, Oh BH, Irving M, Coukos G, Correia BE. Giordano-Attianese G, et al. Among authors: bonet j. Nat Biotechnol. 2020 Apr;38(4):503. doi: 10.1038/s41587-020-0461-z. Nat Biotechnol. 2020. PMID: 32127717
Bottom-up de novo design of functional proteins with complex structural features.
Yang C, Sesterhenn F, Bonet J, van Aalen EA, Scheller L, Abriata LA, Cramer JT, Wen X, Rosset S, Georgeon S, Jardetzky T, Krey T, Fussenegger M, Merkx M, Correia BE. Yang C, et al. Among authors: bonet j. Nat Chem Biol. 2021 Apr;17(4):492-500. doi: 10.1038/s41589-020-00699-x. Epub 2021 Jan 4. Nat Chem Biol. 2021. PMID: 33398169
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design.
Schoeder CT, Schmitz S, Adolf-Bryfogle J, Sevy AM, Finn JA, Sauer MF, Bozhanova NG, Mueller BK, Sangha AK, Bonet J, Sheehan JH, Kuenze G, Marlow B, Smith ST, Woods H, Bender BJ, Martina CE, Del Alamo D, Kodali P, Gulsevin A, Schief WR, Correia BE, Crowe JE Jr, Meiler J, Moretti R. Schoeder CT, et al. Among authors: bonet j. Biochemistry. 2021 Mar 23;60(11):825-846. doi: 10.1021/acs.biochem.0c00912. Epub 2021 Mar 11. Biochemistry. 2021. PMID: 33705117 Free PMC article.
RosettaSurf-A surface-centric computational design approach.
Scheck A, Rosset S, Defferrard M, Loukas A, Bonet J, Vandergheynst P, Correia BE. Scheck A, et al. Among authors: bonet j. PLoS Comput Biol. 2022 Mar 16;18(3):e1009178. doi: 10.1371/journal.pcbi.1009178. eCollection 2022 Mar. PLoS Comput Biol. 2022. PMID: 35294435 Free PMC article.
261 results