Bosma KJ - Search Results

1

Pharmacological blockade of the EP3 prostaglandin E₂ receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.

Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.

2

Pharmacological modulation of prostaglandin E₂ (PGE₂ ) EP receptors improves cardiomyocyte function under hyperglycemic conditions.

Bosma KJ, Ghosh M, Andrei SR, Zhong L, Dunn JC, Ricciardi VF, Burkett JB, Hatzopoulos AK, Damron DS, Gannon M. Bosma KJ, et al. Physiol Rep. 2022 Apr;10(7):e15212. doi: 10.14814/phy2.15212. Physiol Rep. 2022. PMID: 35403369 Free PMC article.

3

Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass.

Bosma KJ, Kaiser CE, Kimple ME, Gannon M. Bosma KJ, et al. Metabolites. 2022 Apr 12;12(4):342. doi: 10.3390/metabo12040342. Metabolites. 2022. PMID: 35448529 Free PMC article. Review.

4

Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells.

Rahim M, Nakhe AY, Banerjee DR, Overway EM, Bosma KJ, Rosch JC, Oeser JK, Wang B, Lippmann ES, Jacobson DA, O'Brien RM, Young JD. Rahim M, et al. Among authors: bosma kj. J Biol Chem. 2022 Apr;298(4):101729. doi: 10.1016/j.jbc.2022.101729. Epub 2022 Feb 15. J Biol Chem. 2022. PMID: 35176280 Free PMC article.

5

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.

Overway EM, Bosma KJ, Claxton DP, Oeser JK, Singh K, Breidenbach LB, Mchaourab HS, Davis LK, O'Brien RM. Overway EM, et al. Among authors: bosma kj. J Biol Chem. 2022 Feb;298(2):101534. doi: 10.1016/j.jbc.2021.101534. Epub 2021 Dec 23. J Biol Chem. 2022. PMID: 34954144 Free PMC article.

6

Macrophages and neutrophils are necessary for ER stress-induced β cell loss.

Yang B, Yang L, Wang Y, Maddison LA, Tang Z, Haigh S, Gong Y, Zhang Y, Covington BA, Bosma KJ, Tong X, Page-McCaw P, Gannon M, Deng Q, Chen W. Yang B, et al. Among authors: bosma kj. Cell Rep. 2022 Aug 23;40(8):111255. doi: 10.1016/j.celrep.2022.111255. Cell Rep. 2022. PMID: 36001973 Free PMC article.

7

Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.

Mosleh E, Ou K, Haemmerle MW, Tembo T, Yuhas A, Carboneau BA, Townsend SE, Bosma KJ, Gannon M, O'Brien RM, Stoffers DA, Golson ML. Mosleh E, et al. Among authors: bosma kj. Endocrinology. 2020 Aug 1;161(8):bqaa054. doi: 10.1210/endocr/bqaa054. Endocrinology. 2020. PMID: 32267917 Free PMC article.

8

G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting.

Bosma KJ, Rahim M, Oeser JK, McGuinness OP, Young JD, O'Brien RM. Bosma KJ, et al. Mol Metab. 2020 Nov;41:101043. doi: 10.1016/j.molmet.2020.101043. Epub 2020 Jun 20. Mol Metab. 2020. PMID: 32569842 Free PMC article.

9

Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose.

Bosma KJ, Rahim M, Singh K, Goleva SB, Wall ML, Xia J, Syring KE, Oeser JK, Poffenberger G, McGuinness OP, Means AL, Powers AC, Li WH, Davis LK, Young JD, O'Brien RM. Bosma KJ, et al. J Mol Endocrinol. 2020 May;64(4):235-248. doi: 10.1530/JME-20-0031. J Mol Endocrinol. 2020. PMID: 32213654 Free PMC article.

10

The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content.

Syring KE, Bosma KJ, Oeser JK, Shiota M, O'Brien RM. Syring KE, et al. Among authors: bosma kj. J Mol Evol. 2018 Dec;86(9):613-617. doi: 10.1007/s00239-018-9873-5. Epub 2018 Nov 3. J Mol Evol. 2018. PMID: 30392157 Free PMC article.

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