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Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis.
Neoplasia. 2021 Apr;23(4):415-428. doi: 10.1016/j.neo.2021.03.006. Epub 2021 Apr 8.
Neoplasia. 2021.
PMID: 33839455
Free PMC article.
Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer.
Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Vacca G, Ceci M, Boujnah K, Garbo V, Moschella A, Zappacosta R, Simeone P, de Lange R, Weidle UH, Rotelli MT, Picciariello A, Depalo R, Querzoli P, Pedriali M, Bianchini E, Angelucci D, Pizzicannella G, Di Loreto C, Piantelli M, Antolini L, Sun XF, Altomare DF, Alberti S.
Guerra E, et al. Among authors: boujnah k.
Neoplasia. 2021 Sep;23(9):898-911. doi: 10.1016/j.neo.2021.07.002. Epub 2021 Jul 25.
Neoplasia. 2021.
PMID: 34320447
Free PMC article.
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Phylogenetic conservation of Trop-2 across species-rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks.
Guerra E, Trerotola M, Relli V, Lattanzio R, Boujnah K, Travali N, Moschella A, Todaro P, Pierdomenico L, Di Pietro R, Tinari N, Alberti S.
Guerra E, et al. Among authors: boujnah k.
Front Genet. 2024 Jan 5;14:1297367. doi: 10.3389/fgene.2023.1297367. eCollection 2023.
Front Genet. 2024.
PMID: 38250577
Free PMC article.
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The 2EF Antibody Targets a Unique N-Terminal Epitope of Trop-2 and Enhances the In Vivo Activity of the Cancer-Selective 2G10 Antibody.
Guerra E, Trerotola M, Relli V, Lattanzio R, Ceci M, Boujnah K, Pantalone L, Di Pietro R, Iezzi M, Tinari N, Alberti S.
Guerra E, et al. Among authors: boujnah k.
Cancers (Basel). 2023 Jul 22;15(14):3721. doi: 10.3390/cancers15143721.
Cancers (Basel). 2023.
PMID: 37509383
Free PMC article.
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3D-Informed Targeting of the Trop-2 Signal-Activation Site Drives Selective Cancer Vulnerability.
Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Ceci M, Boujnah K, Pantalone L, Sacchetti A, Havas KM, Simeone P, Travali N, Querzoli P, Pedriali M, Roversi P, Iezzi M, Tinari N, Antolini L, Alberti S.
Guerra E, et al. Among authors: boujnah k.
Mol Cancer Ther. 2023 Jun 1;22(6):790-804. doi: 10.1158/1535-7163.MCT-22-0352.
Mol Cancer Ther. 2023.
PMID: 36921314
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