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Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.
Elhabazi K, Humbert JP, Bertin I, Schmitt M, Bihel F, Bourguignon JJ, Bucher B, Becker JA, Sorg T, Meziane H, Petit-Demoulière B, Ilien B, Simonin F. Elhabazi K, et al. Among authors: bourguignon jj. Neuropharmacology. 2013 Dec;75:164-71. doi: 10.1016/j.neuropharm.2013.07.012. Epub 2013 Aug 2. Neuropharmacology. 2013. PMID: 23911743
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
Elhabazi K, Humbert JP, Bertin I, Quillet R, Utard V, Schneider S, Schmitt M, Bourguignon JJ, Laboureyras E, Ben Boujema M, Simonnet G, Ancel C, Simonneaux V, Beltramo M, Bucher B, Sorg T, Meziane H, Schneider E, Petit-Demoulière B, Ilien B, Bihel F, Simonin F. Elhabazi K, et al. Among authors: bourguignon jj. Neuropharmacology. 2017 May 15;118:188-198. doi: 10.1016/j.neuropharm.2017.03.012. Epub 2017 Mar 10. Neuropharmacology. 2017. PMID: 28288815
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.
Gealageas R, Schneider S, Humbert JP, Bertin I, Schmitt M, Laboureyras E, Dugave C, Mollereau C, Simonnet G, Bourguignon JJ, Simonin F, Bihel F. Gealageas R, et al. Among authors: bourguignon jj. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7471-4. doi: 10.1016/j.bmcl.2012.10.049. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23131340
Development of a peptidomimetic antagonist of neuropeptide FF receptors for the prevention of opioid-induced hyperalgesia.
Bihel F, Humbert JP, Schneider S, Bertin I, Wagner P, Schmitt M, Laboureyras E, Petit-Demoulière B, Schneider E, Mollereau C, Simonnet G, Simonin F, Bourguignon JJ. Bihel F, et al. Among authors: bourguignon jj. ACS Chem Neurosci. 2015 Mar 18;6(3):438-45. doi: 10.1021/cn500219h. Epub 2015 Feb 7. ACS Chem Neurosci. 2015. PMID: 25588572
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.
Simonin F, Schmitt M, Laulin JP, Laboureyras E, Jhamandas JH, MacTavish D, Matifas A, Mollereau C, Laurent P, Parmentier M, Kieffer BL, Bourguignon JJ, Simonnet G. Simonin F, et al. Among authors: bourguignon jj. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. doi: 10.1073/pnas.0502090103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407169 Free PMC article.
100 results