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Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M. Putoczki TL, et al. Among authors: boussioutas a. Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017. Cancer Cell. 2013. PMID: 23948300 Free article.
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
Thiem S, Pierce TP, Palmieri M, Putoczki TL, Buchert M, Preaudet A, Farid RO, Love C, Catimel B, Lei Z, Rozen S, Gopalakrishnan V, Schaper F, Hallek M, Boussioutas A, Tan P, Jarnicki A, Ernst M. Thiem S, et al. Among authors: boussioutas a. J Clin Invest. 2013 Feb;123(2):767-81. doi: 10.1172/JCI65086. Epub 2013 Jan 16. J Clin Invest. 2013. PMID: 23321674 Free PMC article.
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.
Eissmann MF, Dijkstra C, Jarnicki A, Phesse T, Brunnberg J, Poh AR, Etemadi N, Tsantikos E, Thiem S, Huntington ND, Hibbs ML, Boussioutas A, Grimbaldeston MA, Buchert M, O'Donoghue RJJ, Masson F, Ernst M. Eissmann MF, et al. Among authors: boussioutas a. Nat Commun. 2019 Jun 21;10(1):2735. doi: 10.1038/s41467-019-10676-1. Nat Commun. 2019. PMID: 31227713 Free PMC article.
An orthotopic mouse model of gastric cancer invasion and metastasis.
Busuttil RA, Liu DS, Di Costanzo N, Schröder J, Mitchell C, Boussioutas A. Busuttil RA, et al. Among authors: boussioutas a. Sci Rep. 2018 Jan 16;8(1):825. doi: 10.1038/s41598-017-19025-y. Sci Rep. 2018. PMID: 29339747 Free PMC article.
Immunological battlefield in gastric cancer and role of immunotherapies.
Wang M, Busuttil RA, Pattison S, Neeson PJ, Boussioutas A. Wang M, et al. Among authors: boussioutas a. World J Gastroenterol. 2016 Jul 28;22(28):6373-84. doi: 10.3748/wjg.v22.i28.6373. World J Gastroenterol. 2016. PMID: 27605873 Free PMC article. Review.
156 results