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PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites.
Glas J, Seiderer J, Czamara D, Pasciuto G, Diegelmann J, Wetzke M, Olszak T, Wolf C, Müller-Myhsok B, Balschun T, Achkar JP, Kamboh MI, Franke A, Duerr RH, Brand S. Glas J, et al. Among authors: brand s. PLoS One. 2012;7(12):e52873. doi: 10.1371/journal.pone.0052873. Epub 2012 Dec 27. PLoS One. 2012. PMID: 23300802 Free PMC article.
The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.
Glas J, Seiderer J, Tillack C, Pfennig S, Beigel F, Jürgens M, Olszak T, Laubender RP, Weidinger M, Müller-Myhsok B, Göke B, Ochsenkühn T, Lohse P, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: brand s. PLoS One. 2010 Dec 30;5(12):e14466. doi: 10.1371/journal.pone.0014466. PLoS One. 2010. PMID: 21209938 Free PMC article.
CEACAM6 gene variants in inflammatory bowel disease.
Glas J, Seiderer J, Fries C, Tillack C, Pfennig S, Weidinger M, Beigel F, Olszak T, Lass U, Göke B, Ochsenkühn T, Wolf C, Lohse P, Müller-Myhsok B, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: brand s. PLoS One. 2011 Apr 29;6(4):e19319. doi: 10.1371/journal.pone.0019319. PLoS One. 2011. PMID: 21559399 Free PMC article.
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Glas J, Wagner J, Seiderer J, Olszak T, Wetzke M, Beigel F, Tillack C, Stallhofer J, Friedrich M, Steib C, Göke B, Ochsenkühn T, Karbalai N, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: brand s. PLoS One. 2012;7(3):e33682. doi: 10.1371/journal.pone.0033682. Epub 2012 Mar 21. PLoS One. 2012. PMID: 22457781 Free PMC article.
Analysis of IL12B gene variants in inflammatory bowel disease.
Glas J, Seiderer J, Wagner J, Olszak T, Fries C, Tillack C, Friedrich M, Beigel F, Stallhofer J, Steib C, Wetzke M, Göke B, Ochsenkühn T, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: brand s. PLoS One. 2012;7(3):e34349. doi: 10.1371/journal.pone.0034349. Epub 2012 Mar 30. PLoS One. 2012. PMID: 22479607 Free PMC article.
IRGM variants and susceptibility to inflammatory bowel disease in the German population.
Glas J, Seiderer J, Bues S, Stallhofer J, Fries C, Olszak T, Tsekeri E, Wetzke M, Beigel F, Steib C, Friedrich M, Göke B, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: brand s. PLoS One. 2013;8(1):e54338. doi: 10.1371/journal.pone.0054338. Epub 2013 Jan 24. PLoS One. 2013. PMID: 23365659 Free PMC article.
Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2.
Diegelmann J, Czamara D, Le Bras E, Zimmermann E, Olszak T, Bedynek A, Göke B, Franke A, Glas J, Brand S. Diegelmann J, et al. Among authors: brand s. PLoS One. 2013 Nov 5;8(11):e77773. doi: 10.1371/journal.pone.0077773. eCollection 2013. PLoS One. 2013. PMID: 24223725 Free PMC article.
The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.
Schnitzler F, Friedrich M, Wolf C, Angelberger M, Diegelmann J, Olszak T, Beigel F, Tillack C, Stallhofer J, Göke B, Glas J, Lohse P, Brand S. Schnitzler F, et al. Among authors: brand s. PLoS One. 2014 Nov 3;9(11):e108503. doi: 10.1371/journal.pone.0108503. eCollection 2014. PLoS One. 2014. PMID: 25365249 Free PMC article.
The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations.
Schnitzler F, Friedrich M, Wolf C, Stallhofer J, Angelberger M, Diegelmann J, Olszak T, Tillack C, Beigel F, Göke B, Glas J, Lohse P, Brand S. Schnitzler F, et al. Among authors: brand s. PLoS One. 2015 Jul 6;10(7):e0116044. doi: 10.1371/journal.pone.0116044. eCollection 2015. PLoS One. 2015. PMID: 26147989 Free PMC article.
989 results