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2021 2
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Page 1
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.
Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, Kean LS. Watkins B, et al. Among authors: bratrude b. J Clin Oncol. 2021 Jun 10;39(17):1865-1877. doi: 10.1200/JCO.20.01086. Epub 2021 Jan 15. J Clin Oncol. 2021. PMID: 33449816 Free PMC article. Clinical Trial.
Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events.
Takahashi T, Al-Kofahi M, Jaber M, Bratrude B, Betz K, Suessmuth Y, Yu A, Neuberg DS, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Blazar BR, Horan JT, Watkins B, Langston A, Qayed M, Kean LS. Takahashi T, et al. Among authors: bratrude b. Blood. 2023 Aug 24;142(8):700-710. doi: 10.1182/blood.2023020035. Blood. 2023. PMID: 37319437 Clinical Trial.
Abatacept for the prevention of GVHD in patients receiving mismatched unrelated transplants: a real-world analysis.
Raghunandan S, Gorfinkel L, Graiser M, Bratrude B, Suessmuth Y, Gillespie S, Westbrook AL, Williams KM, Schoettler ML, Kean LS, Horan J, Langston AA, Qayed M, Watkins B. Raghunandan S, et al. Among authors: bratrude b. Blood Adv. 2023 Aug 22;7(16):4395-4399. doi: 10.1182/bloodadvances.2023010225. Blood Adv. 2023. PMID: 37285800 Free PMC article. No abstract available.
Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation.
Qayed M, Watkins B, Gillespie S, Bratrude B, Betz K, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Langston A, Kean LS, Horan JT. Qayed M, et al. Among authors: bratrude b. Blood Adv. 2022 Feb 8;6(3):746-749. doi: 10.1182/bloodadvances.2021005208. Blood Adv. 2022. PMID: 34753172 Free PMC article. No abstract available.
Overlap chronic GVHD is associated with adverse survival outcomes compared to classic chronic GVHD.
Gorfinkel L, Raghunandan S, Watkins B, Hebert K, Neuberg DS, Bratrude B, Betz K, Yu A, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Blazar BR, Horan JT, Langston A, Kean LS, Qayed M. Gorfinkel L, et al. Among authors: bratrude b. Bone Marrow Transplant. 2024 May;59(5):680-687. doi: 10.1038/s41409-024-02245-y. Epub 2024 Feb 21. Bone Marrow Transplant. 2024. PMID: 38383714
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease.
Tkachev V, Kaminski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan JT, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS. Tkachev V, et al. Among authors: bratrude b. Sci Transl Med. 2021 Jan 13;13(576):eabc0227. doi: 10.1126/scitranslmed.abc0227. Sci Transl Med. 2021. PMID: 33441422 Free PMC article.
Abatacept for graft versus host disease prophylaxis in patients 60 years and older receiving mismatched unrelated donor transplantation for hematologic malignancies.
Raghunandan S, Qayed M, Watkins BK, Graiser M, Gorfinkel L, Westbrook A, Gillespie S, Bratrude B, Petrovic A, Suessmuth Y, Horan J, Kean LS, Langston AA. Raghunandan S, et al. Among authors: bratrude b. Bone Marrow Transplant. 2023 Nov;58(11):1264-1266. doi: 10.1038/s41409-023-02043-y. Epub 2023 Aug 14. Bone Marrow Transplant. 2023. PMID: 37580397 Free PMC article. No abstract available.
Abatacept for the prevention of graft versus host disease in pediatric patients receiving 7/8 HLA-mismatched unrelated transplant for hematologic malignancies: a real-world analysis.
Raghunandan S, Gorfinkel L, Bratrude B, Suessmuth Y, Hebert K, Neuberg D, Williams KM, Schoettler ML, Langston AA, Kean LS, Qayed M, Horan J, Watkins BK. Raghunandan S, et al. Among authors: bratrude b. Bone Marrow Transplant. 2023 Nov;58(11):1260-1263. doi: 10.1038/s41409-023-02034-z. Epub 2023 Aug 14. Bone Marrow Transplant. 2023. PMID: 37580396 Free PMC article. No abstract available.
The Adverse Event Landscape of Stem Cell Transplant: Evidence for aGVHD Driving Early Transplant Associated Toxicities.
Takahashi T, Watkins B, Bratrude B, Neuberg D, Hebert K, Betz K, Yu A, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Blazar BR, Horan JT, Langston A, Kean LS, Qayed M. Takahashi T, et al. Among authors: bratrude b. Transplant Cell Ther. 2024 Apr 6:S2666-6367(24)00317-8. doi: 10.1016/j.jtct.2024.03.030. Online ahead of print. Transplant Cell Ther. 2024. PMID: 38583802