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The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: brandon ae. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.
Brandon AE, Liao BM, Diakanastasis B, Parker BL, Raddatz K, McManus SA, O'Reilly L, Kimber E, van der Kraan AG, Hancock D, Henstridge DC, Meikle PJ, Cooney GJ, James DE, Reibe S, Febbraio MA, Biden TJ, Schmitz-Peiffer C. Brandon AE, et al. Cell Metab. 2019 Jan 8;29(1):183-191.e7. doi: 10.1016/j.cmet.2018.09.013. Epub 2018 Oct 11. Cell Metab. 2019. PMID: 30318338 Free article.
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA. Findeisen M, et al. Among authors: brandon ae. Nature. 2019 Oct;574(7776):63-68. doi: 10.1038/s41586-019-1601-9. Epub 2019 Sep 25. Nature. 2019. PMID: 31554967
Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health.
Wali JA, Milner AJ, Luk AWS, Pulpitel TJ, Dodgson T, Facey HJW, Wahl D, Kebede MA, Senior AM, Sullivan MA, Brandon AE, Yau B, Lockwood GP, Koay YC, Ribeiro R, Solon-Biet SM, Bell-Anderson KS, O'Sullivan JF, Macia L, Forbes JM, Cooney GJ, Cogger VC, Holmes A, Raubenheimer D, Le Couteur DG, Simpson SJ. Wali JA, et al. Among authors: brandon ae. Nat Metab. 2021 Jun;3(6):810-828. doi: 10.1038/s42255-021-00393-9. Epub 2021 Jun 8. Nat Metab. 2021. PMID: 34099926
Insulin controls food intake and energy balance via NPY neurons.
Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Brüning JC, Cooney G, Neely GG, Herzog H. Loh K, et al. Mol Metab. 2017 Apr 12;6(6):574-584. doi: 10.1016/j.molmet.2017.03.013. eCollection 2017 Jun. Mol Metab. 2017. PMID: 28580287 Free PMC article.
Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.
Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Solon-Biet SM, et al. Among authors: brandon ae. Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29. Nat Metab. 2019. PMID: 31656947 Free PMC article.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL. Alexopoulos SJ, et al. Among authors: brandon ae. Nat Commun. 2020 May 14;11(1):2397. doi: 10.1038/s41467-020-16298-2. Nat Commun. 2020. PMID: 32409697 Free PMC article.
Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance.
Nelson ME, Madsen S, Cooke KC, Fritzen AM, Thorius IH, Masson SWC, Carroll L, Weiss FC, Seldin MM, Potter M, Hocking SL, Fazakerley DJ, Brandon AE, Thillainadesan S, Senior AM, Cooney GJ, Stöckli J, James DE. Nelson ME, et al. Among authors: brandon ae. Cell Metab. 2022 Feb 1;34(2):227-239.e6. doi: 10.1016/j.cmet.2021.12.013. Epub 2022 Jan 11. Cell Metab. 2022. PMID: 35021042 Free article.
Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice.
Hocking SL, Stewart RL, Brandon AE, Suryana E, Stuart E, Baldwin EM, Kolumam GA, Modrusan Z, Junutula JR, Gunton JE, Medynskyj M, Blaber SP, Karsten E, Herbert BR, James DE, Cooney GJ, Swarbrick MM. Hocking SL, et al. Among authors: brandon ae. Diabetologia. 2015 Jul;58(7):1587-600. doi: 10.1007/s00125-015-3583-y. Epub 2015 Apr 22. Diabetologia. 2015. PMID: 25899451
44 results