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EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.
Kerr HL, Krumm K, Lee II, Anderson B, Christiani A, Strait L, Breckheimer BA, Irwin B, Jiang AS, Rybachok A, Chen A, Caeiro L, Dacek E, Hall DB, Kostyla CH, Hales LM, Soliman TM, Garcia JM. Kerr HL, et al. Among authors: breckheimer ba. J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1337-1348. doi: 10.1002/jcsm.13211. Epub 2023 Mar 21. J Cachexia Sarcopenia Muscle. 2023. PMID: 36942661 Free PMC article.
Growth hormone secretagogue receptor-1a mediates ghrelin's effects on attenuating tumour-induced loss of muscle strength but not muscle mass.
Liu H, Zang P, Lee II, Anderson B, Christiani A, Strait-Bodey L, Breckheimer BA, Storie M, Tewnion A, Krumm K, Li T, Irwin B, Garcia JM. Liu H, et al. Among authors: breckheimer ba. J Cachexia Sarcopenia Muscle. 2021 Oct;12(5):1280-1295. doi: 10.1002/jcsm.12743. Epub 2021 Jul 15. J Cachexia Sarcopenia Muscle. 2021. PMID: 34264027 Free PMC article.