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Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Wainger BJ, et al. Among authors: brenneis c. Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24. Nat Neurosci. 2015. PMID: 25420066 Free PMC article.
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJ. Cronin SJF, et al. Among authors: brenneis c. Sci Transl Med. 2022 Aug 31;14(660):eabj1531. doi: 10.1126/scitranslmed.abj1531. Epub 2022 Aug 31. Sci Transl Med. 2022. PMID: 36044597 Free PMC article.
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. Sisignano M, et al. Among authors: brenneis c. J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012. J Neurosci. 2012. PMID: 22553041 Free PMC article.
Inhibition of cyclooxygenases by dipyrone.
Pierre SC, Schmidt R, Brenneis C, Michaelis M, Geisslinger G, Scholich K. Pierre SC, et al. Among authors: brenneis c. Br J Pharmacol. 2007 Jun;151(4):494-503. doi: 10.1038/sj.bjp.0707239. Epub 2007 Apr 16. Br J Pharmacol. 2007. PMID: 17435797 Free PMC article.
Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2).
Gao W, Schmidtko A, Lu R, Brenneis C, Angioni C, Schmidt R, Geisslinger G. Gao W, et al. Among authors: brenneis c. Eur J Pharmacol. 2009 Apr 17;608(1-3):28-31. doi: 10.1016/j.ejphar.2009.01.051. Epub 2009 Feb 26. Eur J Pharmacol. 2009. PMID: 19249295
132 results