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p21 as a transcriptional co-repressor of S-phase and mitotic control genes.
Ferrándiz N, Caraballo JM, García-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC, Bretones G, Quintanilla A, Muñoz-Alonso MJ, Blanco R, Reyes JC, Agell N, Delgado MD, Dotto GP, León J. Ferrándiz N, et al. Among authors: bretones g. PLoS One. 2012;7(5):e37759. doi: 10.1371/journal.pone.0037759. Epub 2012 May 25. PLoS One. 2012. PMID: 22662213 Free PMC article.
MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.).
Gómez-Casares MT, García-Alegria E, López-Jorge CE, Ferrándiz N, Blanco R, Alvarez S, Vaqué JP, Bretones G, Caraballo JM, Sánchez-Bailón P, Delgado MD, Martín-Perez J, Cigudosa JC, León J. Gómez-Casares MT, et al. Among authors: bretones g. Oncogene. 2013 Apr 25;32(17):2239-46. doi: 10.1038/onc.2012.246. Epub 2012 Jun 18. Oncogene. 2013. PMID: 22710719
Myc and cell cycle control.
Bretones G, Delgado MD, León J. Bretones G, et al. Biochim Biophys Acta. 2015 May;1849(5):506-16. doi: 10.1016/j.bbagrm.2014.03.013. Epub 2014 Apr 1. Biochim Biophys Acta. 2015. PMID: 24704206 Free article. Review.
High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle.
Caraballo JM, Acosta JC, Cortés MA, Albajar M, Gómez-Casares MT, Batlle-López A, Cuadrado MA, Onaindia A, Bretones G, Llorca J, Piris MA, Colomer D, León J. Caraballo JM, et al. Among authors: bretones g. Oncotarget. 2014 Jul 15;5(13):4694-708. doi: 10.18632/oncotarget.2100. Oncotarget. 2014. PMID: 25051361 Free PMC article.
CD3ε recruits Numb to promote TCR degradation.
Martin-Blanco N, Jiménez Teja D, Bretones G, Borroto A, Caraballo M, Screpanti I, León J, Alarcón B, Canelles M. Martin-Blanco N, et al. Among authors: bretones g. Int Immunol. 2016 Mar;28(3):127-37. doi: 10.1093/intimm/dxv060. Epub 2015 Oct 27. Int Immunol. 2016. PMID: 26507128
26 results