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Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: brooks sv. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32. doi: 10.1152/ajpcell.00372.2009. Epub 2009 Sep 23. Am J Physiol Cell Physiol. 2009. PMID: 19776389 Free PMC article.
The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase.
Vasilaki A, van der Meulen JH, Larkin L, Harrison DC, Pearson T, Van Remmen H, Richardson A, Brooks SV, Jackson MJ, McArdle A. Vasilaki A, et al. Among authors: brooks sv. Aging Cell. 2010 Dec;9(6):979-90. doi: 10.1111/j.1474-9726.2010.00635.x. Epub 2010 Oct 29. Aging Cell. 2010. PMID: 20883524 Free PMC article.
Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation.
Larkin LM, Davis CS, Sims-Robinson C, Kostrominova TY, Van Remmen H, Richardson A, Feldman EL, Brooks SV. Larkin LM, et al. Among authors: brooks sv. Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1400-7. doi: 10.1152/ajpregu.00093.2011. Epub 2011 Sep 7. Am J Physiol Regul Integr Comp Physiol. 2011. PMID: 21900648 Free PMC article.
121 results