Broom HR - Search Results

1

Concurrent Increases and Decreases in Local Stability and Conformational Heterogeneity in Cu, Zn Superoxide Dismutase Variants Revealed by Temperature-Dependence of Amide Chemical Shifts.

Doyle CM, Rumfeldt JA, Broom HR, Sekhar A, Kay LE, Meiering EM. Doyle CM, et al. Among authors: broom hr. Biochemistry. 2016 Mar 8;55(9):1346-61. doi: 10.1021/acs.biochem.5b01133. Epub 2016 Feb 22. Biochemistry. 2016. PMID: 26849066

2

Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis.

Broom HR, Rumfeldt JA, Meiering EM. Broom HR, et al. Essays Biochem. 2014;56:149-65. doi: 10.1042/bse0560149. Essays Biochem. 2014. PMID: 25131593

3

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways.

Sekhar A, Rumfeldt JA, Broom HR, Doyle CM, Bouvignies G, Meiering EM, Kay LE. Sekhar A, et al. Among authors: broom hr. Elife. 2015 Jun 23;4:e07296. doi: 10.7554/eLife.07296. Elife. 2015. PMID: 26099300 Free PMC article.

4

Combined Isothermal Titration and Differential Scanning Calorimetry Define Three-State Thermodynamics of fALS-Associated Mutant Apo SOD1 Dimers and an Increased Population of Folded Monomer.

Broom HR, Vassall KA, Rumfeldt JA, Doyle CM, Tong MS, Bonner JM, Meiering EM. Broom HR, et al. Biochemistry. 2016 Jan 26;55(3):519-33. doi: 10.1021/acs.biochem.5b01187. Epub 2016 Jan 13. Biochemistry. 2016. PMID: 26710831

5

Energetics of oligomeric protein folding and association.

Doyle CM, Rumfeldt JA, Broom HR, Broom A, Stathopulos PB, Vassall KA, Almey JJ, Meiering EM. Doyle CM, et al. Among authors: broom hr. Arch Biochem Biophys. 2013 Mar;531(1-2):44-64. doi: 10.1016/j.abb.2012.12.005. Epub 2012 Dec 13. Arch Biochem Biophys. 2013. PMID: 23246784 Review.

6

Destabilization of the dimer interface is a common consequence of diverse ALS-associated mutations in metal free SOD1.

Broom HR, Rumfeldt JA, Vassall KA, Meiering EM. Broom HR, et al. Protein Sci. 2015 Dec;24(12):2081-9. doi: 10.1002/pro.2803. Epub 2015 Oct 5. Protein Sci. 2015. PMID: 26362407 Free PMC article.

7

Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy.

Sekhar A, Rumfeldt JAO, Broom HR, Doyle CM, Sobering RE, Meiering EM, Kay LE. Sekhar A, et al. Among authors: broom hr. Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E6939-E6945. doi: 10.1073/pnas.1611418113. Epub 2016 Oct 24. Proc Natl Acad Sci U S A. 2016. PMID: 27791136 Free PMC article.

8

Immature ALS-associated mutant superoxide dismutases form variable aggregate structures through distinct oligomerization processes.

Deol HK, Broom HR, Siebeneichler B, Lee B, Leonenko Z, Meiering EM. Deol HK, et al. Among authors: broom hr. Biophys Chem. 2022 Sep;288:106844. doi: 10.1016/j.bpc.2022.106844. Epub 2022 Jun 9. Biophys Chem. 2022. PMID: 35872467

9

ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.

Pickles S, Semmler S, Broom HR, Destroismaisons L, Legroux L, Arbour N, Meiering E, Cashman NR, Vande Velde C. Pickles S, et al. Among authors: broom hr. Acta Neuropathol Commun. 2016 Apr 27;4(1):43. doi: 10.1186/s40478-016-0313-8. Acta Neuropathol Commun. 2016. PMID: 27121871 Free PMC article.

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