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Page 1
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: brunotte l. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.
Weber M, Sediri H, Felgenhauer U, Binzen I, Bänfer S, Jacob R, Brunotte L, García-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, Klenk HD, Weber F. Weber M, et al. Among authors: brunotte l. Cell Host Microbe. 2015 Mar 11;17(3):309-319. doi: 10.1016/j.chom.2015.01.005. Epub 2015 Feb 19. Cell Host Microbe. 2015. PMID: 25704008 Free PMC article.
Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics.
Kumar S, Çalışkan DM, Janowski J, Faist A, Conrad BCG, Lange J, Ludwig S, Brunotte L. Kumar S, et al. Among authors: brunotte l. Front Immunol. 2021 Oct 1;12:752227. doi: 10.3389/fimmu.2021.752227. eCollection 2021. Front Immunol. 2021. PMID: 34659259 Free PMC article. Review.
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses.
Schreiber A, Viemann D, Schöning J, Schloer S, Mecate Zambrano A, Brunotte L, Faist A, Schöfbänker M, Hrincius E, Hoffmann H, Hoffmann M, Pöhlmann S, Rescher U, Planz O, Ludwig S. Schreiber A, et al. Among authors: brunotte l. Cell Mol Life Sci. 2022 Jan 10;79(1):65. doi: 10.1007/s00018-021-04085-1. Cell Mol Life Sci. 2022. PMID: 35013790 Free PMC article.
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseases.
Schloer S, Treuherz D, Faist A, de Witt M, Wunderlich K, Wiewrodt R, Wiebe K, Barth P, Wälzlein JH, Kummer S, Balkema-Buschmann A, Ludwig S, Brunotte L, Rescher U. Schloer S, et al. Among authors: brunotte l. Emerg Microbes Infect. 2022 Dec;11(1):2160-2175. doi: 10.1080/22221751.2022.2117101. Emerg Microbes Infect. 2022. PMID: 36000328 Free PMC article.
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. Faist A, et al. Among authors: brunotte l. Antiviral Res. 2023 Jan;209:105475. doi: 10.1016/j.antiviral.2022.105475. Epub 2022 Nov 21. Antiviral Res. 2023. PMID: 36423831 Free PMC article.
The ubiquitination landscape of the influenza A virus polymerase.
Günl F, Krischuns T, Schreiber JA, Henschel L, Wahrenburg M, Drexler HCA, Leidel SA, Cojocaru V, Seebohm G, Mellmann A, Schwemmle M, Ludwig S, Brunotte L. Günl F, et al. Among authors: brunotte l. Nat Commun. 2023 Feb 11;14(1):787. doi: 10.1038/s41467-023-36389-0. Nat Commun. 2023. PMID: 36774438 Free PMC article.
40 results