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BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models.
Vervloessem T, Sasi BK, Xerxa E, Karamanou S, Kale J, La Rovere RM, Chakraborty S, Sneyers F, Vogler M, Economou A, Laurenti L, Andrews DW, Efremov DG, Bultynck G. Vervloessem T, et al. Among authors: bultynck g. Cell Death Dis. 2020 Sep 17;11(9):769. doi: 10.1038/s41419-020-02944-6. Cell Death Dis. 2020. PMID: 32943617 Free PMC article.
Bcl-2 binds to and inhibits ryanodine receptors.
Vervliet T, Decrock E, Molgó J, Sorrentino V, Missiaen L, Leybaert L, De Smedt H, Kasri NN, Parys JB, Bultynck G. Vervliet T, et al. Among authors: bultynck g. J Cell Sci. 2014 Jun 15;127(Pt 12):2782-92. doi: 10.1242/jcs.150011. Epub 2014 Apr 24. J Cell Sci. 2014. PMID: 24762814
The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.
Monaco G, Decrock E, Arbel N, van Vliet AR, La Rovere RM, De Smedt H, Parys JB, Agostinis P, Leybaert L, Shoshan-Barmatz V, Bultynck G. Monaco G, et al. Among authors: bultynck g. J Biol Chem. 2015 Apr 3;290(14):9150-61. doi: 10.1074/jbc.M114.622514. Epub 2015 Feb 13. J Biol Chem. 2015. PMID: 25681439 Free PMC article.
Antagonizing Bcl-2's BH4 domain in cancer.
Vervloessem T, La Rovere R, Bultynck G. Vervloessem T, et al. Among authors: bultynck g. Aging (Albany NY). 2015 Oct;7(10):748-9. doi: 10.18632/aging.100828. Aging (Albany NY). 2015. PMID: 26525307 Free PMC article. No abstract available.
245 results