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Did you mean c or nan ferre[Author] (3,348,404 results)?
Alterations in Proteostasis Mechanisms in Niemann-Pick Type C Disease.
Servín Muñoz IV, Ortuño-Sahagún D, Griñán-Ferré C, Pallàs M, González-Castillo C. Servín Muñoz IV, et al. Among authors: grinan ferre c. Int J Mol Sci. 2024 Mar 29;25(7):3806. doi: 10.3390/ijms25073806. Int J Mol Sci. 2024. PMID: 38612616 Free PMC article. Review.
Niemann-Pick Type C (NPC) represents an autosomal recessive disorder with an incidence rate of 1 in 150,000 live births, classified within lysosomal storage diseases (LSDs). ...
Niemann-Pick Type C (NPC) represents an autosomal recessive disorder with an incidence rate of 1 in 150,000 live births, classified w …
Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics.
Griñán-Ferré C, Jarné-Ferrer J, Bellver-Sanchís A, Codony S, Puigoriol-Illamola D, Sanfeliu C, Oh Y, Lee S, Vázquez S, Pallàs M. Griñán-Ferré C, et al. CNS Neurosci Ther. 2024 Apr;30(4):e14511. doi: 10.1111/cns.14511. Epub 2023 Oct 31. CNS Neurosci Ther. 2024. PMID: 37905690 Free PMC article.
RESULTS: UB-SCG-51 (10 and 30 muM) prevented neurotoxic reactive-astrocyte conversion in primary mouse astrocytes challenged with TNF-alpha, IL-1alpha, and C1q (T/I/C) combination for 24 h. Moreover, in microglial cultures, sEHi reduced inflammation and glial activity. ... …
RESULTS: UB-SCG-51 (10 and 30 muM) prevented neurotoxic reactive-astrocyte conversion in primary mouse astrocytes challenged with TNF-alpha, …
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors.
Codony S, Entrena JM, Calvó-Tusell C, Jora B, González-Cano R, Osuna S, Corpas R, Morisseau C, Pérez B, Barniol-Xicota M, Griñán-Ferré C, Pérez C, Rodríguez-Franco MI, Martínez AL, Loza MI, Pallàs M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vázquez S. Codony S, et al. Among authors: grinan ferre c. J Med Chem. 2022 Oct 27;65(20):13660-13680. doi: 10.1021/acs.jmedchem.2c00515. Epub 2022 Oct 12. J Med Chem. 2022. PMID: 36222708 Free PMC article.
Repurposing of Raltitrexed as an Effective G9a/EHMT2 Inhibitor and Promising Anti-Alzheimer's Agent.
Jana A, Bellver-Sanchis A, Griñán-Ferré C, Banerjee DR. Jana A, et al. Among authors: grinan ferre c. ACS Med Chem Lett. 2023 Oct 12;14(11):1531-1536. doi: 10.1021/acsmedchemlett.3c00344. eCollection 2023 Nov 9. ACS Med Chem Lett. 2023. PMID: 37974951
Moreover, raltitrexed lowers the total H3K9me2/H3K9 levels in AD transgenic C. elegans CL2006 worms, indicating that raltitrexed targets G9a directly. As toxicity is the bottleneck in G9a drug discovery, we conducted detailed in silico toxicity (TOPKAT) analyses of raltitr …
Moreover, raltitrexed lowers the total H3K9me2/H3K9 levels in AD transgenic C. elegans CL2006 worms, indicating that raltitrexed targ …
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Turcu AL, Companys-Alemany J, Phillips MB, Patel DS, Griñán-Ferré C, Loza MI, Brea JM, Pérez B, Soto D, Sureda FX, Kurnikova MG, Johnson JW, Pallàs M, Vázquez S. Turcu AL, et al. Among authors: grinan ferre c. Eur J Med Chem. 2022 Jun 5;236:114354. doi: 10.1016/j.ejmech.2022.114354. Epub 2022 Apr 8. Eur J Med Chem. 2022. PMID: 35453065 Free PMC article.
The excellent in vitro DMPK properties of IIc made it a promising candidate for in vivo studies in Caenorhabditis elegans (C. elegans) and in the 5XFAD mouse model of AD. Administration of IIc or memantine improved locomotion and rescues chemotaxis behavior in C. el …
The excellent in vitro DMPK properties of IIc made it a promising candidate for in vivo studies in Caenorhabditis elegans (C. elegans …
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. Codony S, et al. Among authors: grinan ferre c. J Med Chem. 2022 Mar 24;65(6):4909-4925. doi: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271276 Free PMC article.
From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis.
Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S. Codony S, et al. Among authors: grinan ferre c. J Med Chem. 2021 May 13;64(9):5429-5446. doi: 10.1021/acs.jmedchem.0c01601. Epub 2021 May 4. J Med Chem. 2021. PMID: 33945278 Free PMC article.
19 results