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1993 5
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283 results

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Page 1
Understanding prion structure and conversion.
Spagnolli G, Requena JR, Biasini E. Spagnolli G, et al. Among authors: requena jr. Prog Mol Biol Transl Sci. 2020;175:19-30. doi: 10.1016/bs.pmbts.2020.07.005. Epub 2020 Sep 11. Prog Mol Biol Transl Sci. 2020. PMID: 32958233 Review.
For almost four decades, the high-resolution structure of PrP(Sc), the infectious and misfolded counterpart of the cellular prion protein (PrP(C)), has remained elusive, mostly due to technical challenges posed by its high insolubility and aggregation propensity. ...
For almost four decades, the high-resolution structure of PrP(Sc), the infectious and misfolded counterpart of the cellular prion protein (P …
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.
Chowell D, Morris LGT, Grigg CM, Weber JK, Samstein RM, Makarov V, Kuo F, Kendall SM, Requena D, Riaz N, Greenbaum B, Carroll J, Garon E, Hyman DM, Zehir A, Solit D, Berger M, Zhou R, Rizvi NA, Chan TA. Chowell D, et al. Among authors: requena d. Science. 2018 Feb 2;359(6375):582-587. doi: 10.1126/science.aao4572. Epub 2017 Dec 7. Science. 2018. PMID: 29217585 Free PMC article.
We determined the HLA-I genotype of 1535 advanced cancer patients treated with immune checkpoint blockade (ICB). Maximal heterozygosity at HLA-I loci ("A," "B," and "C") improved overall survival after ICB compared with patients who were homozygous for at least one HLA loc …
We determined the HLA-I genotype of 1535 advanced cancer patients treated with immune checkpoint blockade (ICB). Maximal heterozygosity at H …
Farmalarm.
Requena M, Montiel E, Baladas M, Muchada M, Boned S, López R, Rodríguez-Villatoro N, Juega J, García-Tornel Á, Rodríguez-Luna D, Pagola J, Rubiera M, Molina CA, Ribo M. Requena M, et al. Stroke. 2019 Jul;50(7):1819-1824. doi: 10.1161/STROKEAHA.118.024355. Epub 2019 Jun 6. Stroke. 2019. PMID: 31167621
Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study.
Yaghi S, Shu L, Mandel D, Leon Guerrero CR, Henninger N, Muppa J, Affan M, Ul Haq Lodhi O, Heldner MR, Antonenko K, Seiffge D, Arnold M, Salehi Omran S, Crandall R, Lester E, Lopez Mena D, Arauz A, Nehme A, Boulanger M, Touze E, Sousa JA, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito MT, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann JE, Engelter ST, Traenka C, Aguiar de Sousa D, Soares M, Rosa S, Zhou LW, Gandhi P, Field TS, Mancini S, Metanis I, Leker RR, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte CH, Choi R, MacDonald J, Bavarsad Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego EA, Sanchez S, Rioux B, Zine-Eddine F, Poppe A, Fonseca AC, Baptista MF, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind DS, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy-Rivas R, Aziz Y, Bakradze E, Tran TL, Rodrigo-Gisbert M, Requena M, Saleh Velez F, Ortiz Gracia J, Mudassani V, de Havenon A, Vishnu VY, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer … See abstract for full author list ➔ Yaghi S, et al. Among authors: requena m. Stroke. 2024 Apr;55(4):908-918. doi: 10.1161/STROKEAHA.123.045731. Epub 2024 Feb 9. Stroke. 2024. PMID: 38335240 Free article.
Occlusive Nonvasculitic Vasculopathy.
Llamas-Velasco M, Alegría V, Santos-Briz Á, Cerroni L, Kutzner H, Requena L. Llamas-Velasco M, et al. Among authors: requena l. Am J Dermatopathol. 2017 Sep;39(9):637-662. doi: 10.1097/DAD.0000000000000766. Am J Dermatopathol. 2017. PMID: 27759698 Review.
Microorganisms may also occlude the vessels lumina and this is especially frequent in ecthyma gangrenosum, opportunistic fungi as aspergillosis or fusariosis, Lucio phenomenon of lepromatous leprosy and disseminated strongyloidiasis. Systemic coagulopathies due to defects of C …
Microorganisms may also occlude the vessels lumina and this is especially frequent in ecthyma gangrenosum, opportunistic fungi as aspergillo …
When to Stop.
García-Tornel Á, Requena M, Rubiera M, Muchada M, Pagola J, Rodriguez-Luna D, Deck M, Juega J, Rodríguez-Villatoro N, Boned S, Olivé-Gadea M, Tomasello A, Hernández D, Molina CA, Ribo M. García-Tornel Á, et al. Among authors: requena m. Stroke. 2019 Jul;50(7):1781-1788. doi: 10.1161/STROKEAHA.119.025088. Epub 2019 Jun 10. Stroke. 2019. PMID: 31177974
A tetracationic porphyrin with dual anti-prion activity.
Masone A, Zucchelli C, Caruso E, Lavigna G, Eraña H, Giachin G, Tapella L, Comerio L, Restelli E, Raimondi I, Elezgarai SR, De Leo F, Quilici G, Taiarol L, Oldrati M, Lorenzo NL, García-Martínez S, Cagnotto A, Lucchetti J, Gobbi M, Vanni I, Nonno R, Di Bari MA, Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R. Masone A, et al. Among authors: requena jr. iScience. 2023 Jul 27;26(9):107480. doi: 10.1016/j.isci.2023.107480. eCollection 2023 Sep 15. iScience. 2023. PMID: 37636075 Free PMC article.
Prions are deadly infectious agents made of PrP(Sc), a misfolded variant of the cellular prion protein (PrP(C)) which self-propagates by inducing misfolding of native PrP(C). ...We identified Zn(II)-BnPyP, a tetracationic porphyrin that binds to distinct domains of …
Prions are deadly infectious agents made of PrP(Sc), a misfolded variant of the cellular prion protein (PrP(C)) which self-propagates …
The Structure of PrPSc Prions.
Wille H, Requena JR. Wille H, et al. Among authors: requena jr. Pathogens. 2018 Feb 7;7(1):20. doi: 10.3390/pathogens7010020. Pathogens. 2018. PMID: 29414853 Free PMC article. Review.
While the structure of PrP(C) is well studied, the structure of PrP(Sc) resisted high-resolution determination due to its general insolubility and propensity to aggregate. ...Here, we summarize the current knowledge regarding the structure of PrP(Sc) and speculate about th …
While the structure of PrP(C) is well studied, the structure of PrP(Sc) resisted high-resolution determination due to its general ins …
ALWAYS ICSI? A SWOT analysis.
Bosch E, Espinós JJ, Fabregues F, Fontes J, García-Velasco J, Llácer J, Requena A, Checa MA, Bellver J; Spanish Infertility SWOT Group (SISG). Bosch E, et al. Among authors: requena a. J Assist Reprod Genet. 2020 Sep;37(9):2081-2092. doi: 10.1007/s10815-020-01836-0. Epub 2020 Jun 24. J Assist Reprod Genet. 2020. PMID: 32578032 Free PMC article. Review.
Plasmacytic cutaneous pathology: A review.
Walsh NM, Kutzner H, Requena L, Cerroni L. Walsh NM, et al. Among authors: requena l. J Cutan Pathol. 2019 Sep;46(9):698-708. doi: 10.1111/cup.13499. Epub 2019 Jul 3. J Cutan Pathol. 2019. PMID: 31095757 Review.
It is structured along histopathological lines, addressing conditions characterized by (a) cutaneous plasma cell infiltrates, (b) deposits of plasma cell products or their derivatives in the skin and (c) miscellaneous, poorly understood cutaneous complications of plasmacyt …
It is structured along histopathological lines, addressing conditions characterized by (a) cutaneous plasma cell infiltrates, (b) deposits o …
283 results